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CAS RN: 192725-17-0 | Product Number: L0377
Lopinavir
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Purity: >98.0%(HPLC)
Synonyms:
- (S)-N-[(2S,4S,5S)-5-[2-(2,6-Dimethylphenoxy)acetamido]-4-hydroxy-1,6-diphenylhexan-2-yl]-3-methyl-2-(2-oxotetrahydropyrimidin-1(2H)-yl)butanamide
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
Shipping Information
|
|---|---|---|---|---|---|
| 250MG |
51,00 €
|
5 | 9 |
|
|
| 1G |
175,00 €
|
2 | 8 |
|
* Stock available in Belgium: Shipment on the same day
* Stock available in Japan: Please check the Shipping Simulation for estimated shipments. (excludes regulated items and dry ice shipments)
| Product Number | L0377 |
Purity / Analysis Method 
|
>98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__3__7H__4__8N__4O__5 = 628.81 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Frozen (-20°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| Packaging and Container
|
1G-Glass Bottle with Plastic Insert (View image), 250MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 192725-17-0 |
| Reaxys Registry Number | 9309881 |
| PubChem Substance ID | 468592179 |
| MDL Number | MFCD22628840 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Melting point | 103.0 to 107.0 °C |
| Specific rotation | -22.0.0 to -26.0.0 deg(C=0.4, mathanol |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 105 °C |
| Solubility in water | Insoluble |
| Solubility (soluble in) | Ethanol, Methanol |
GHS
Related Laws:
| RTECS# | UV6264135 |
Transport Information:
| HS Number | 2933599590 |
Application
Lopinavir: A HIV-1 Protease Inhibitor
Lopinavir (ABT-378), a HIV-1 protease inhibitor, prevents cleavage of the Gag-Pol polyprotein, resulting in the production of immature, non-infectious viral particles.1,2) In clinical, lopinavir is co-formulated with ritonavir [R0116] to enhance the bioavailability and pharmacokinetics of lopinavir.3) Ritonavir inhibits the CYP3A-mediated metabolism of lopinavir, thereby providing increased plasma levels of lopinavir. In the 2020s, it has been reported that lopinavir is an effective agent that inhibits the protease activity of corona viruses, such as SARS-CoV2 and MERS.4,5) (The product is for research purpose only.)
References
- 1) ABT-378, a Highly Potent Inhibitor of the Human Immunodeficiency Virus Protease
- 2) Human Serum Attenuates the Activity of Protease Inhibitors toward Wild-Type and Mutant Human Immunodeficiency Virus
- 3) Lopinavir-ritonavir: A new protease inhibitor (a review)
- 4) Remdesivir, lopinavir, emetine, and homoharringtonine inhibit SARS-CoV-2 replication in vitro
- 5) A systematic review of lopinavir therapy for SARS coronavirus and MERS coronavirus-A possible reference for coronavirus disease-19 treatment option
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