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CAS RN: 2446-83-5 | 产品编码: A1246
Diisopropyl Azodicarboxylate (40% in Toluene, ca. 1.9mol/L)
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| 产品编码 | A1246 |
| 分子式/分子量 | C__8H__1__4N__2O__4 = 202.21 |
| 外观与形状（20°C） | 液体 |
储存温度 
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冷藏 (0-10°C) |
| 应避免的情况 | 光,加热 |
| CAS RN | 2446-83-5 |
| Reaxys-RN | 5262252 |
| MDL编号 | MFCD00008875 |
技术规格
| Appearance | Light yellow to Amber to Dark green clear liquid |
| Concentration(Iodometric titration) | 40.0 to 44.0 w/w% |
| NMR | confirm to structure |
物性（参考值）
| 比重 | 0.94 |
| 折射率 | 1.47 |
GHS
| 象形图 |
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| 信号词 | Danger |
| 危险性说明 | H312 + H332 : Harmful in contact with skin or if inhaled. H315 + H320 : Causes skin and eye irritation. H360 : May damage fertility or the unborn child. H370 : Causes damage to organs. H372 : Causes damage to organs through prolonged or repeated exposure. H335 : May cause respiratory irritation. H336 : May cause drowsiness or dizziness. H304 : May be fatal if swallowed and enters airways. H401 : Toxic to aquatic life. H225 : Highly flammable liquid and vapor. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P273 : Avoid release to the environment. P260 : Do not breathe dust/ fume/ gas/ mist/ vapors/ spray. P270 : Do not eat, drink or smoke when using this product. P202 : Do not handle until all safety precautions have been read and understood. P240 : Ground/bond container and receiving equipment. P210 : Keep away from heat/sparks/open flames/hot surfaces. No smoking. P233 : Keep container tightly closed. P201 : Obtain special instructions before use. P243 : Take precautionary measures against static discharge. P241 : Use explosion-proof electrical/ ventilating/ lighting/ equipment. P242 : Use only non-sparking tools. P271 : Use only outdoors or in a well-ventilated area. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P370 + P378 : In case of fire: Use dry sand, dry chemical or alcohol-resistant foam to extinguish. P331 : Do NOT induce vomiting. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P308 + P311 : IF exposed or concerned: Call a POISON CENTER/doctor. P362 + P364 : Take off contaminated clothing and wash it before reuse. P303 + P361 + P353 : IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/shower. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P301 + P310 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. P304 + P340 + P312 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Call a POISON CENTER/doctor if you feel unwell. P403 + P233 : Store in a well-ventilated place. Keep container tightly closed. P403 + P235 : Store in a well-ventilated place. Keep cool. P405 : Store locked up. |
相关法规
运输信息
| UN编号 | UN1993 |
| 类别 | 3 |
| 包装类别 | II |
| HS编码* | 2927.00-000 |
应用
TCI Practical Example: Mitsunobu Reaction using DIAD
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Used Chemicals
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Procedure
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To a solution of triphenylphosphine (0.88 g, 3.4 mmol), 5-mercapto-1-phenyl-1H-tetrazole (0.79 g 4.4 mmol), 3-phenylpropan-1-ol (0.30 g, 2.2 mmol) in anhydrous tetrahydrofuran (22 mL) was added DIAD (40% in toluene, 2.1 mL, 4.0 mmol) at 0 °C and the mixture was stirred at rt for 1 hour. The solution was dropped into water (40 mL). The mixture was extracted with ethyl acetate (40 mL x 3), and organic phase was dried over sodium sulfate and filtered. The solvent was removed under reduced pressure and the residue was purified by column chromatography (ethyl acetate:hexane = 1:9 on silica gel) to give 1 (0.68 g, quant) as a white solid.
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Experimenter’s Comments
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The reaction mixture was monitored by TLC (ethyl acetate:hexane = 1:9, Rf = 0.29).
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Analytical Data
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Compound 1
1H NMR (400 MHz, CDCl3); δ 7.63-7.50 (m, 5H), 7.35-7.26 (m, 2H), 7.23-7.14 (m, 3H), 3.40 (t, J = 7.0 Hz, 2H), 2.79 (t, J = 7.6 Hz, 2H), 2.18 (quin, J = 7.3 Hz, 2H)
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Lead Reference
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- One-Pot Substitution of Aliphatic Alcohols Mediated by Sulfuryl Fluoride
PubMed Literature
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