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CAS RN: 137848-28-3 | 产品编码: A2316
(R)-(+)-2-Amino-2'-hydroxy-1,1'-binaphthyl
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技术规格
物性（参考值）
| 熔点 | 173 °C |
| 比旋光度 [α]D | 120° (C=1,THF) |
GHS
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| 信号词 | Danger |
| 危险性说明 | H318 : Causes serious eye damage. H413 : May cause long lasting harmful effects to aquatic life. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P273 : Avoid release to the environment. P280 : Wear eye protection/ face protection. P305 + P351 + P338 + P310 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER/doctor. |
相关法规
运输信息
| HS编码* | 2922.29-000 |
应用
Asymmetric synthesis of amino acids using NOBIN as a phase-transfer catalyst
Typical procedure (asymmetric alkylation of (2) under phase-transfer catalysis condition): Finely ground NaOH (2 g), glycine equivalent (2) (2.1 g) and (R)-NOBIN (0.14 g) in anhydrous CH2Cl2 (30 mL) are stirred under Ar at 15-20 °C for 3 min. Then BnBr (1 g) is added, and the mixture is stirred for 8 min. The reaction mixture is quenched by the addition of aq. AcOH (10 mL) and diluted with CH2Cl2 (30 mL). The organic layer is separated and concentrated. The residue is purified by flash chromatography on silica gel (eluent: CHCl3/acetone) to give (3) (2.3 g, 90%, 97 % ee). The crude complex (3) is crystallized from C6H6/acetone to give the enantiomerically pure product (3) (1.9 g, 74 %).
References
参考文献