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CAS RN: 38819-10-2 | 产品编码: A2739
9-β-D-Arabinofuranosylguanine
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补充产品信息:
Previously this product had been labeled as a hydrate form both in product name and molecular formula. The hydrate form had no exclusive CAS RN and used to share the same CAS RN as the anhydrous form.
To avoid any misleading information and since moisture in product is considered as an impurity, we have decided to remove the term 'Hydrate' from product name and 'xH2O' from the molecular formula for such products.
Please use it at ease since there is no difference in product quality, even if you see the previous indications on a part of label.
| 产品编码 | A2739 |
纯度/分析方法 
|
>98.0%(HPLC) |
| 分子式/分子量 | C__1__0H__1__3N__5O__5 = 283.24 |
| 外观与形状（20°C） | 固体 |
| 储存温度
|
冷藏 (0-10°C) |
| 应避免的情况 | 加热 |
| 包装和容器
|
10MG-Glass Bottle with Plastic Insert （查看图片）, 50MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 38819-10-2 |
| Reaxys-RN | 1225954 |
| PubChem物质ID | 253662300 |
| MDL编号 | MFCD00065486 |
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Elemental analysis(Nitrogen) | 24.00% to 25.50% (calcd.on anh.substance) |
| Water | 4.0 to 7.0 % |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 225 °C |
| 最大吸收波长 | 252 nm |
GHS
相关法规
| RTECS# | MF8301000 |
运输信息
| HS编码* | 2934.99-000 |
应用
Ara-G: An Inhibitor of DNA Replication in T-Leukemic Cells
Arabinosylguanine (ara-G) is triphosphorylated by multiple kinases intracellularly to the active nucleotide, ara-GTP, which inhibits the DNA replication in T-leukemic cells. Ara-G is used for the treatment of T-cell acute lymphoblastic leukemia (T-ALL) or T-cell lymphoblastic lymphoma (T-LBL). From the 2000s, nelarabine (the 6-methoxy pro-drug of ara-G) have been introduced and used for the treatment of T-All and T-LBL. In organic synthesis, ara-G is used as an intermediate for the synthesis of guanosine analogs. (The product is for research purpose only.)
References
- Selective toxicity of deoxyguanosine and arabinosyl guanine for T-leukemic cells
- Metabolic basis of arabinonucleoside selectivity for human leukemic T- and B-lymphoblasts
- Transport and metabolism of 9-β-D-arabinofuranosylguanine in a human T-lymphoblastoid cell line: nitrobenzylthioinosine-sensitive and -insensitive influx
- Nelarabine in the treatment of refractory T-cell malignancies (a review)
- Synthesis of 2'-iodo- and 2'-bromo-ATP and GTP analogs as potential phasing tools for X-ray crystallography
- Synthesis, Oxidation Behavior, Crystallization and Structure of 2'-Methylseleno Guanosine Containing RNAs
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