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CAS RN: 301836-41-9 | 产品编码: B4003
SB 431542
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| 产品编码 | B4003 |
| 纯度/分析方法 | >97.0%(HPLC) |
| 分子式/分子量 | C__2__2H__1__6N__4O__3 = 384.40 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 冷冻 (<0°C) |
| 应避免的情况 | 加热 |
| 包装和容器 | 100MG-Glass Bottle with Plastic Insert （查看图片）, 25MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 301836-41-9 |
| Reaxys-RN | 9086247 |
| PubChem物质ID | 468590503 |
| MDL编号 | MFCD05865244 |
技术规格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 97.0 area% |
| Water | max. 3.0 % |
物性（参考值）
| 熔点 | 214 °C(dec.) |
GHS
相关法规
运输信息
| HS编码* | 2933.39-000 |
应用
SB-431542: A Selective Inhibitor TGF-β Type I Receptor Kinase
SB-431542 is a selective inhibitor (or an antagonist) of the transforming growth factor-β superfamily type I (TGF-β type I) receptor kinase. It has been reported that SB-431542 suppresses the proliferation of tumor cells, and evaluates the differential ability of ES and iPS cells.
References
- SB-431542 is a potent and specific inhibitor of transforming growth factor-β superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7
- Inhibition of transforming growth factor (TGF)-β1-induced extracellular matrix with a novel inhibitor of the TGF-β type i receptor kinase activity: SB-431542
- Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling
- Escape from Pluripotency via Inhibition of TGF-β/BMP and Activation of Wnt Signaling Accelerates Differentiation and Aging in hPSC Progeny Cells
- 3つの小分子化合物を用いてヒトiPS細胞の分化能力を促進する基盤技術を開発
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