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CAS RN: 58-08-2 | 产品编码: C2042
Caffeine
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技术规格
| Appearance | White to Almost white powder to crystaline |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Solubility in hot Methanol | almost transparency |
物性（参考值）
| 熔点 | 238 °C |
| 水溶性 | 微溶 |
| 在水中的溶解度 | 21.7 g/l |
| 溶解性（可溶于） | 氯仿 |
| 溶解性（微溶于） | 醇, 丙酮, 苯 |
GHS
| 象形图 |
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| 信号词 | Danger |
| 危险性说明 | H301 : Toxic if swallowed. H332 : Harmful if inhaled. H360 : May damage fertility or the unborn child. H412 : Harmful to aquatic life with long lasting effects. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P261 : Avoid breathing dust/ fume/ gas/ mist/ vapors/ spray. P273 : Avoid release to the environment. P270 : Do not eat, drink or smoke when using this product. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P271 : Use only outdoors or in a well-ventilated area. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P304 + P340 + P312 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Call a POISON CENTER/doctor if you feel unwell. P405 : Store locked up. |
相关法规
| RTECS# | EV6475000 |
运输信息
| UN编号 | UN1544 |
| 类别 | 6.1 |
| 包装类别 | III |
| HS编码* | 2939.30-000 |
应用
Caffeine: A Non-Selective Adenosine Receptor Antagonist, and an Inhibitor Cell Cycle of Progression
Caffeine is widely contained in foods and beverages and is the most widely consumed central-nervous-system stimulant.1) It has been known that adenosine is a modulator that has a pervasive and generally inhibitory effect on neuronal activity. Caffeine, a mimic of adenosine, has the opposite effect of adenosine, and causes most of its biological effects via antagonizing all types of adenosine receptors (ARs), such as A1, A2A, A3, and A2B.2) Besides, it has been reported that caffeine is capable of abrogating cell cycle checkpoints in several different mammalian cell types.3,4) Caffeine has been used to help delineate the role of p53 (cellular tumor antigen p53 gene) in the G2 arrest that occurs in response to DNA damage.3) (The product is for research purpose only.)
References
- 1) Actions of caffeine in the brain with special reference to factors that contribute to its widespread use (a review)
- 2) Caffeine and adenosine (a review)
- 3) Regulation of the G2/M transition by p53 (a review)
- 4) The enigmatic effects of caffeine in cell cycle and cancer (a review)
参考文献
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