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CAS RN: 482577-59-3 | 产品编码: C2475
N-(2'-Cyanobiphenyl-4-ylmethyl)-L-valine Methyl Ester Hydrochloride
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| 产品编码 | C2475 |
| 纯度/分析方法 | >98.0%(T)(HPLC) |
| 分子式/分子量 | C__2__0H__2__2N__2O__2·HCl = 358.87 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 室温 (15°C以下阴凉干燥处) |
| CAS RN | 482577-59-3 |
| 相关CAS RN | 137863-89-9 |
| PubChem物质ID | 160871372 |
| MDL编号 | MFCD08460094 |
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Specific rotation [a]20/D | +17.0 to +21.0 deg(C=1, MeOH) |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 187 °C(dec.) |
| 比旋光度 [α]D | 19° (C=1,MeOH) |
| 溶解性（可溶于） | 甲醇 |
GHS
| 象形图 |
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| 信号词 | Warning |
| 危险性说明 | H302 + H312 + H332 : Harmful if swallowed, in contact with skin or if inhaled. H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P261 : Avoid breathing dust/ fume/ gas/ mist/ vapors/ spray. P270 : Do not eat, drink or smoke when using this product. P271 : Use only outdoors or in a well-ventilated area. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. P302 + P352 + P312 : IF ON SKIN: Wash with plenty of water.Call a POISON CENTER/doctor if you feel unwell. P304 + P340 + P312 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Call a POISON CENTER/doctor if you feel unwell. |
相关法规
运输信息
| HS编码* | 2926.90-000 |
应用
A Key Synthetic Intermediate of Valsartan
This product has been used as a key synthetic intermediate of valsartan [V0112] which is an antagonist of the angiotensin II AT1-receptor subtype.
References
- Synthesis of Valsartan via Decarboxylative Biaryl Coupling
- An Efficient and Telescopic Process for Valsartan, an Angiotensin II Receptor Blocker
- Stability-indicating UPLC method for determination of Valsartan and their degradation products in active pharmaceutical ingredient and pharmaceutical dosage forms
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