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CAS RN: 163042-96-4 | 产品编码: C3601
Chloro-IB-MECA
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技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Melting point | 207.0 to 211.0 °C |
| Elemental analysis(Nitrogen) | 14.70 to 16.20 % |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 209 °C |
GHS
相关法规
运输信息
| HS编码* | 2934.99-000 |
应用
Cl-IB-MECA: A Selective Antagonist of the Adenosine A3 Receptor
Cl-IB-MECA is a selective antagonist of the adenosine A3 receptor (A3R), which is one of the four subtypes of adenosine receptors (A1R, A2AR, A2BR, and A3R). Cl-IB-MECA is selective for the A3R, displaying 2500 and 1400-fold selectivity over A1R and A2AR, respectively.1) The A3R is the only adenosine subtype to be overexpressed in inflammatory and cancer cells, thus making it a potential target for therapy.2-6) (The product is for research purpose only.)
References
- 1) Adenosine A3 receptors: novel ligands and paradoxical effects
- 2) Induction of apoptosis in HL-60 human promyelocytic leukemia cells by adenosine A3 receptor agonists
- 3) Disruption of the A3 adenosine receptor gene in mice and its effect on stimulated inflammatory cells
- 4) Modulation of the A3 adenosine receptor by low agonist concentration induces antitumor and myelostimulatory effects (a review)
- 5) Medicinal chemistry of the A3 adenosine receptor: agonists, antagonists, and receptor engineering (a review)
- 6) Adenosine A3 receptor activation attenuates lungischemia-reperfusion injury
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