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CAS RN: 4097-22-7 | 产品编码: D3065
2',3'-Dideoxyadenosine
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This product is a sample for RUO (research use only). Do not use this product for any purpose other than testing and research.
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 186.0 to 190.0 °C |
| Specific rotation [a]20/D | -27.0 to -34.0 deg(C=1, H2O) |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 188 °C |
| 比旋光度 [α]D | -34° (C=1,H2O) |
GHS
| 象形图 |
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| 信号词 | Warning |
| 危险性说明 | H341 : Suspected of causing genetic defects. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P405 : Store locked up. |
相关法规
| RTECS# | AU7358900 |
运输信息
| HS编码* | 2940.00-000 |
应用
2',3'-Dideoxyadenosine (ddA): A Nucleoside Reverse Transcriptase Inhibitor
2',3'-Dideoxyadenosine (ddA) and didanosine (ddI) [D3066] are nucleoside reverse transcriptase inhibitors. ddA is a synthetic nucleoside analogue of the naturally occurring nucleoside 2’-deoxyadenosine in which the 3'-hydroxyl group is replaced by hydrogen. Intracellularly, ddA and ddI are converted by cellular enzymes to the active metabolite, ddA- 5'-triphosphate. The triphosphate inhibits the activity of viral reverse transcriptase both by competing with the natural substrate, 2’-deoxyadenosine-5'-triphosphate, and by its incorporation into viral DNA causing termination of viral DNA chain. (The product is for research purpose only.)
References
- Inhibition of the in vitro infectivity and cytopathic effect of human T-lymphotrophic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV) by 2',3'-dideoxynucleosides
- Long-term inhibition of human T-lymphotropic virus type III/lymphadenopathy-associated virus (human immunodeficiency virus) DNA synthesis and RNA expression in T cells protected by 2',3'-dideoxynucleosides in vitro
- Metabolic pathways for the activation of the antiretroviral agent 2',3'-dideoxyadenosine in human lymphoid cells.
- Initial studies on the cellular pharmacology of 2',3'-dideoxyadenosine, an inhibitor of HTLV-III infectivity
- Toxicity of Nucleoside Analogues Used to Treat AIDS and the Selectivity of the Mitochondrial DNA Polymerase (a review)
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