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CAS RN: 3056-17-5 | 产品编码: D3580
2',3'-Didehydro-3'-deoxythymidine
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This product is a sample for RUO (research use only). Do not use this product for any purpose other than testing and research.
| 产品编码 | D3580 |
纯度/分析方法 
|
>98.0%(T)(HPLC) |
| 分子式/分子量 | C__1__0H__1__2N__2O__4 = 224.22 |
| 外观与形状（20°C） | 固体 |
| 储存温度
|
室温 (15°C以下阴凉干燥处) |
| 包装和容器
|
1G-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 3056-17-5 |
| Reaxys-RN | 618327 |
| PubChem物质ID | 87559878 |
| SDBS (AIST Spectral DB) | 52178 |
| MDL编号 | MFCD00132921 |
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
| Specific rotation [a]20/D | -44.0 to -48.0 deg(C=0.69, H2O) |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 166 °C(dec.) |
| 比旋光度 [α]D | -46° (C=0.69,H2O) |
| 水溶性 | 可溶 |
GHS
| 象形图 |
|
| 信号词 | Warning |
| 危险性说明 | H373 : May cause damage to organs through prolonged or repeated exposure. H341 : Suspected of causing genetic defects. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P260 : Do not breathe dust/ fume/ gas/ mist/ vapors/ spray. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P405 : Store locked up. |
相关法规
| RTECS# | XP2075000 |
运输信息
| HS编码* | 2940.00-000 |
应用
Stavudine: A Nucleoside Reverse Transcriptase Inhibitor
Stavudine is a nucleoside reverse transcriptase inhibitor that active against HIV1. Stavudine is a synthetic nucleoside analogue of the naturally occurring nucleoside thymidine. Intracellularly, stavudine is converted by cellular enzymes to the active metabolite, stavudine-5'-triphosphate. The triphosphate inhibits the activity of viral reverse transcriptase both by competing with the natural substrate, thymidine-5'-triphosphate, and by its incorporation into viral DNA causing termination of viral DNA chain. (The product is for research purpose only.)
References
- Potent and selective in vitro activity of 3'-deoxythymidin-2'-ene (3'-deoxy-2',3'-didehydrothymidine) against human immunodeficiency virus
- Antiretroviral activity of stavudine (2',3'-didehydro-3'-deoxythymidine, D4T) (a review)
- Comparison of metabolism and in vitro antiviral activity of stavudine versus other 2',3'-dideoxynucleoside analogues
应用
Synthesis and Anti-HIV-1 Activities of Novel Podophyllotoxin Derivatives Containing Stavudine
References
PubMed Literature
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