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CAS RN: 7226-77-9 | 产品编码: D4220
2'-Deoxy-5-(hydroxymethyl)cytidine
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| 产品编码 | D4220 |
纯度/分析方法 
|
>98.0%(T) |
| 分子式/分子量 | C__1__0H__1__5N__3O__5 = 257.25 |
| 外观与形状（20°C） | 固体 |
| 储存温度
|
室温 (15°C以下阴凉干燥处) |
| 包装和容器
|
200MG-Glass Bottle with Plastic Insert （查看图片）, 50MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 7226-77-9 |
| Reaxys-RN | 28741 |
| PubChem物质ID | 253660378 |
| MDL编号 | MFCD09842113 |
技术规格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
物性（参考值）
| 熔点 | 205 °C |
| 最大吸收波长 | 274 nm (H__2O) |
GHS
相关法规
运输信息
| HS编码* | 2934.99-000 |
应用
2'-Deoxy-5-(hydroxymethyl)cytidine (5-hmdC): the Sixth Nucleoside of the Genome
2'-Deoxy-5-(hydroxymethyl)cytidine (5-hmdC) and its base 5-hydroxymethylcytosine (5-hmC) were recently discovered as an oxidation product of 2’-deoxy-5-methylcytidine [D3610] in mammalian DNA, particularly in stem cell DNA. The function of 5-hmdC is currently not clear, but it is assumed that in stem cells they might be intermediates of an active demethylation process. The detecting 5-hmdC in a genome has been investigated.
References
- The Discovery of 5-Formylcytosine in Embryonic Stem Cell DNA
- 5-Hydroxymethylcytosine, the Sixth Base of the Genome (Minireview)
- 5-Hydroxymethylcytosine Is Strongly Depleted in Human Cancers but Its Levels Do Not Correlate with IDH1 Mutations
- Determination of genomic 5-hydroxymethyl-2'-deoxycytidine in human DNA by capillary electrophoresis with laser-induced fluorescence
- Discrimination between 5-hydroxymethylcytosine and 5-methylcytosine in DNA by selective chemical labeling
- Deamination, Oxidation, and C–C Bond Cleavage Reactivity of 5-Hydroxymethylcytosine, 5-Formylcytosine, and 5-Carboxycytosine
参考文献
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