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CAS RN: 53-85-0 | 产品编码: D4292
5,6-Dichlorobenzimidazole 1-β-D-Ribofuranoside
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| 产品编码 | D4292 |
纯度/分析方法 
|
>98.0%(HPLC)(N) |
| 分子式/分子量 | C__1__2H__1__2Cl__2N__2O__4 = 319.14 |
| 外观与形状（20°C） | 固体 |
| 储存温度
|
冷冻 (<0°C) |
| 应避免的情况 | 加热 |
| 包装和容器
|
100MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 53-85-0 |
| Reaxys-RN | 39123 |
| PubChem物质ID | 253660379 |
| MDL编号 | MFCD00036785 |
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(with Total Nitrogen) | min. 98.0 % |
| Melting point | 220.0 to 224.0 °C |
| Specific rotation [a]20/D | -66.0 ～ -68.0 deg(C=2, Pyridine) |
物性（参考值）
| 熔点 | 222 °C |
| 比旋光度 [α]D | -67° (C=2,Pyridine) |
| 最大吸收波长 | 296 nm |
GHS
相关法规
| RTECS# | DD7310000 |
运输信息
| HS编码* | 2934.99-000 |
应用
5,6-Dichlorobenzimidazole 1-β-D-ribofuranoside (DRB): A Selective Inhibitor of Transcription Elongation by RNA Polymerase II
5,6-Dichlorobenzimidazole 1-β-D-ribofuranoside (DRB) is a selective inhibitor of transcription elongation by RNA polymerase II, and then it inhibits of mRNA synthesis in eukaryotic cells. The inhibition can trigger p53-dependent apotosis of tumor cells. DRB can also inhibit HIV transcription by targeting elongation enhanced by the HIV-encoded transactivator (Tat).
References
- 5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole inhibits transcription elongation by RNA polymerase II in vitro
- The transcriptional elongation inhibitor 5,6-dichloro-1-β-D-ribofuranosylbenzimidazole inhibits transcription factor IIH-associated protein kinase
- Inhibition of RNA polymerase II as a trigger for the p53 response
- DSIF and NELF interact with RNA polymerase II elongation complex and HIV-1 Tat stimulates P-TEFb-mediated phosphorylation of RNA polymerase II and DSIF during transcription elongation
- Halogen Bonds Form the Basis for Selective P-TEFb Inhibition by DRB
参考文献
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