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CAS RN: 163622-50-2 | 产品编码: I1161
5-Iodo-7H-pyrrolo[2,3-d]pyrimidin-4-amine
![5-Iodo-7H-pyrrolo[2,3-d]pyrimidin-4-amine Chemical Structure of 5-Iodo-7H-pyrrolo[2,3-d]pyrimidin-4-amine](/medias/I1161.jpg?context=bWFzdGVyfHJvb3R8MjcwMTZ8aW1hZ2UvanBlZ3xhRGsyTDJneVpDODVNek00TVRreU1ETTFPRGN3TDBreE1UWXhMbXB3Wnd8MWJmZjYzNWY4MjJjYTBmYTUwNWEyMDdkZWE0NzlkNTBiYTE5MjJmNjQ0NDdkZjU3YjZmYTczNTMzN2IzYWFkNw)
产品编码 | I1161 |
纯度/分析方法 ![]() |
>95.0%(T)(HPLC) |
分子式/分子量 | C__6H__5IN__4 = 260.04 |
外观与形状(20°C) | 固体 |
储存温度 ![]() |
室温 (15°C以下阴凉干燥处) |
储存在惰性气体下 | 存放于惰性气体之中 |
应避免的情况 | 空气 |
包装和容器 ![]() |
1G-Glass Bottle with Plastic Insert (查看图片) |
CAS RN | 163622-50-2 |
Reaxys-RN | 27008569 |
MDL编号 | MFCD13619882 |
技术规格
Appearance | White to Brown powder to crystal |
Purity(HPLC) | min. 95.0 area% |
Purity(Nonaqueous Titration) | min. 95.0 % |
NMR | confirm to structure |
物性(参考值)
GHS
象形图 |
![]() |
信号词 | Warning |
危险性说明 | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
防范说明 | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
相关法规
运输信息
HS编码* | 2933.59-000 |
应用
A Synthetic Intermediate of Pyrrolo[2,3-d]pyrimidin-Based Derivative Kinase Inhibitors
This product has been used as a synthetic intermediate of pyrrolo[2,3-d]pyrimidin-based derivative kinase inhibitors,1-4) including nucleoside analogs4) such as 5-Iodotubercidin [I1156].
References
- 1) Inhibition of Calcium Dependent Protein Kinase 1 (CDPK1) by Pyrazolopyrimidine Analogs Decreases Establishment and Reoccurrence of Central Nervous System Disease by Toxoplasma gondii
- 2) Identification of 5-(2,3-Dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine derivatives as a new class of receptor-interacting protein kinase 1 (RIPK1) inhibitors, which showed potent activity in a tumor metastasis model
- 3) Identification of Pyrrolo[2,3-d]pyrimidine-Based Derivatives as Potent and Orally Effective Fms-like Tyrosine Receptor Kinase 3 (FLT3) Inhibitors for Treating Acute Myelogenous Leukemia
- 4) Bromo-deaza-SAH: A potent and selective DOT1L inhibitor
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技术规格
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