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CAS RN: 6112-76-1 | 产品编码: M0063
6-Mercaptopurine Monohydrate
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技术规格
| Appearance | Light yellow to Yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
| Water | 9.9 to 11.5 % |
物性（参考值）
GHS
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| 信号词 | Warning |
| 危险性说明 | H302 : Harmful if swallowed. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
相关法规
| RTECS# | UP0400000 |
运输信息
| HS编码* | 2933.99-000 |
应用
6-Mercaptopurine: An Inhibitor of Purine Ribonucleotides and DNA/RNA Synthesis
6-Mercaptopurine (6-MP) is the first effective agent for leukemia, developed by Elion and Hitchings in 1950s. They shared the Nobel Prize in 1988. In cell, 6-MP is converted to 6-thioinosine monophosphate (TIMP), catalyzed by hypoxanthine guanine phosphoribosyltransferase (HPRT). TIMP inhibits conversion of inosinic acid to adenylosuccinic acid and xanthylic acid, subsequently leading to inhibition of purine ribonucleotides and DNA/RNA synthesis. Azathioprine [A2069] is a prodrug of 6-MP, and both are commonly used as an immunosuppressant for treatment of Crohn’s and inflammatory bowel disease. (The product is for research purpose only.)
References
- Historical background of 6-mercaptopurine
- Human liver thiopurine methyltransferase pharmacogenetics: biochemical properties, liver-erythrocyte correlation and presence of isozymes
- Differing contribution of thiopurine methyltransferase to mercaptopurine versus thioguanine effects in human leukemic cells
- CD28-dependent Rac1 activation is the molecular target of azathioprine in primary human CD4+ T lymphocytes
- High-performance liquid chromatographic assay of the methyl and nucleotide metabolites of 6-mercaptopurine: quantitation of red blood cell 6-thioguanine nucleotide, 6-thioinosinic acid and 6-methylmercaptopurine metabolites in a single sample
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