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CAS RN: 192927-63-2 | 产品编码: M2479
Moxifloxacin Hydrochloride Monohydrate
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纯度/分析方法: >98.0%(T)(HPLC)
别名：
- 莫西沙星盐酸盐 一水合物
- 1-环丙基-6-氟-1,4-二氢-8-甲氧基-7-[(4aS,7aS)-十氢-1H-吡咯并[3,4-b]吡啶-6-基]-4-氧代-3-喹啉甲酸盐酸盐 一水合物
- 1-Cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-[(4aS,7aS)-octahydro-1H-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo-3-quinolinecarboxylic Acid Hydrochloride Monohydrate
产品文档：
| 产品编码 | M2479 |
纯度/分析方法 
|
>98.0%(T)(HPLC) |
| 分子式/分子量 | C__2__1H__2__4FN__3O__4·HCl·H__2O = 455.92 |
| 外观与形状（20°C） | 固体 |
| 储存温度
|
室温 (15°C以下阴凉干燥处) |
| 包装和容器
|
100MG-Glass Bottle with Plastic Insert （查看图片）, 1G-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 192927-63-2 |
| 相关CAS RN
|
186826-86-8&151096-09-2 |
| Reaxys-RN | 8377447 |
| PubChem物质ID | 354334556 |
| Merck Index (14) | 6291 |
| MDL编号 | MFCD00949117 |
技术规格
| Appearance | White to Orange to Green powder to crystaline |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
| Specific rotation [a]20/D | -124 to -137 deg(C=0.5, water) |
| Water | 3.0 to 5.0 % |
物性（参考值）
| 熔点 | 240 °C(dec.) |
| 最大吸收波长 | 338 nm (H__2O) |
GHS
| 象形图 |
|
| 信号词 | Warning |
| 危险性说明 | H341 : Suspected of causing genetic defects. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P405 : Store locked up. |
相关法规
| RTECS# | VB1983750 |
运输信息
| HS编码* | 2933.49-000 |
应用
Moxifloxacin Hydrochloride: A Fluoroquinolone Antibacterial with a Methoxy Group in the C-8 Position
Moxifloxacin hydrochloride (BAY 12-8039) is a synthetic fluoroquinolone antibacterial agent with in vitro activity against a wide range of Gram-positive and Gram-negative bacteria. The bactericidal action of moxifloxacin results from inhibition of the topoisomerase II (DNA gyrase) in Gram-negative bacteria and topoisomerase IV in Gram-positive bacteria required for bacterial DNA replication, transcription, repair, and recombination. It is reported that the C8-methoxy moiety contributes to enhanced activity and lower selection of resistant mutants of Gram-positive bacteria compared to the C8-H moiety. Therefore, moxifloxacin has improved activity against Gram-positive species (including staphylococci, streptococci, enterococci) compared with ciprofloxacin [ C2510, C2227 (HCl salt)]. Recently, antituberculosis activity of moxifloxacin has been reported. (The product is for research purpose only.)
References
- 1)In vitro Activity of BAY 12-8039, a New 8-Methoxyquinolone
- 2)The effect of moxifloxacin on its target topoisomerases from Escherichia coli and Staphylococcus aureus
- 3)In vitro and in vivo activities of moxifloxacin and clinafloxacin against Mycobacterium tuberculosis
- 4)Moxifloxacin: A review of its use in the management of bacterial infections
- 5)Simultaneous determination of levofloxacin, gatifloxacin and moxifloxacin in serum by liquid chromatography with column switching
- 6)Optimization of separation and determination of moxifloxacin and its related substances by RP-HPLC
- 7)Solubility of Antibiotics in Different Solvents. 1. Hydrochloride Forms of Tetracycline, Moxifloxacin, and Ciprofloxacin
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