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CAS RN: 481-49-2 | 产品编码: M2968
Cepharanthine
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纯度/分析方法: >90.0%(T)
别名：
- 千金藤素
- O-甲基头花千金藤醇灵碱
- O-Methylcepharanoline
- (15S,31R)-36,54-Dimethoxy-16,32-dimethyl-15,16,17,18,31,32,33,34-octahydro-2,6-dioxa-1(4,5)-[1,3]dioxolo[4,5-g]isoquinolina-3(7,1)-isoquinolina-5(1,3),7(1,4)-dibenzenacyclooctaphane
- 6',12'-Dimethoxy-2,2'-dimethyl-6,7-[methylenebis(oxy)]oxyacanthan
产品文档：
补充产品信息:
This product is a sample for RUO (research use only). Do not use this product for any purpose other than testing and research.
| 产品编码 | M2968 |
纯度/分析方法 
|
>90.0%(T) |
| 分子式/分子量 | C__3__7H__3__8N__2O__6 = 606.72 |
| 外观与形状（20°C） | 固体 |
| 储存温度
|
冷藏 (0-10°C) |
| 储存在惰性气体下 | 存放于惰性气体之中 |
| 应避免的情况 | 光,湿气 (分解),加热 |
| 包装和容器
|
1G-Glass Bottle with Plastic Insert （查看图片）, 250MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 481-49-2 |
| Reaxys-RN | 75231 |
| PubChem物质ID | 468592241 |
| MDL编号 | MFCD00210482 |
技术规格
| Appearance | White to Orange to Green powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Purity(Nonaqueous Titration) | min. 90.0 % |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 152 °C |
| 最大吸收波长 | 219 nm (EtOH) |
GHS
| 象形图 |
|
| 信号词 | Warning |
| 危险性说明 | H302 : Harmful if swallowed. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
相关法规
| RTECS# | FK0527000 |
运输信息
| HS编码* | 2939.79-000 |
应用
Autophagy research
References
- Natural small-molecule enhancers of autophagy induce autophagic cell death in apoptosis-defective cells
应用
Cepharanthine: An Alkaloid with Multiple Pharmacological Properties
Cepharanthine is a naturally occurring alkaloid contained in the plant Stephania cepharantha HAYATA which has been widely used as a herb to treat a variety of diseases, and as an antidote against the poison of snakes. It has been reported that cepharanthine exerts multiple pharmacological properties including anti-oxidative, anti-inflammatory, immuno-regulatory, anti-cancer, anti-viral and anti-parasitic properties with multifactorial mechanisms.1-3) Recently, it has also been reported that cepharanthine or combining cepharanthine/nelfinavir [N0986] enhanced their predicted efficacy to control coronavirus proliferation, including SARS-CoV-2.4,5) (The product is for research purpose only.)
References
- 1) The effects of biscoclaurine alkaloid cepharanthine on mammalian cells: Implications for cancer, shock, and inflammatory diseases
- 2) Antioxidant activity of bisbenzylisoquinoline alkaloids from Stephania rotunda: cepharanthine and fangchinoline
- 3) Cepharanthine: An update of its mode of action, pharmacological properties and medical applications (a review)
- 4) Natural bis-benzylisoquinoline alkaloids- tetrandrine, fangchinoline, and cepharanthine, inhibit human coronavirus OC43 infection of MRC- 5 human lung cells
- 5) Multidrug treatment with nelfinavir and cepharanthine against COVID-19
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