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CAS RN: 20244-86-4 | 产品编码: M3465
7-Methylguanosine
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纯度/分析方法: >85.0%(HPLC)(qNMR)
别名：
- 7-甲基鸟苷
- 2-氨基-6,9-二氢-7-甲基-6-氧代-9-β-D-呋喃核糖基-1H-嘌呤鎓
- 2-氨基-9-[(2R,3R,4S,5R)-3,4-二羟基-5-(羟甲基)四氢呋喃-2-基]-7-甲基-6-氧代-6,9-二氢-3H-嘌呤-7-鎓
- 2-Amino-6,9-dihydro-7-methyl-6-oxo-9-β-D-ribofuranosyl-1H-purinium
- 2-Amino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-7-methyl-6-oxo-6,9-dihydro-3H-purin-7-ium
产品文档：
| 产品编码 | M3465 |
纯度/分析方法 
|
>85.0%(HPLC)(qNMR) |
| 分子式/分子量 | C__1__1H__1__5N__5O__5 = 297.27 |
| 外观与形状（20°C） | 固体 |
| 储存温度
|
冷藏 (0-10°C) |
| 储存在惰性气体下 | 存放于惰性气体之中 |
| 应避免的情况 | 空气,加热 |
| 包装和容器
|
1G-Glass Bottle with Plastic Insert （查看图片）, 200MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 20244-86-4 |
| Reaxys-RN | 3631436 |
| MDL编号 | MFCD16661197 |
技术规格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 85.0 area% |
| Purity(qNMR) | min. 85.0 % |
| Water | max. 11.0 % |
| NMR | confirm to structure |
物性（参考值）
GHS
相关法规
运输信息
| HS编码* | 2934.99-000 |
应用
RNA aptamer research
Reference
- In vitro selection of a 7-methyl-guanosine binding RNA that inhibits translation of capped mRNA molecules
应用
7-Methylguanosine (m7G): The 5' Terminal Cap Structure Present on Eukaryotic mRNA
7-Methylguanosine (m7G) is a purine base modified by the addition of a methyl group and closely resembles the 5' terminal cap structure present on eukaryotic mRNA. The 7-methylguanosine “cap’ is required for the translation of the majority of mRNAs, and it has also been reported to stabilize mRNA against attack by exonucleases and to promote transcription, splicing, polyadenylation and nuclear export of mRNA.1-3) Therefore, efficient mRNA capping enzymatic processes have been studied utilizing 7-methylguanosine.4) In addition, 7-methylguanosine cannot be re-phosphorylated and reused for de novo synthesis, and so is excreted by cells and can be detected in serum and urine. Therefore, it has been used as a biomarker for some types of cancer.5,6) (The product is for research purpose only.)
References
- 1) What messenger RNA capping tells us about eukaryotic evolution (a review)
- 2) Viral and cellular mRNA capping: Past and prospects (a review)
- 3) Regulation of mRNA cap methylation (a review)
- 4) Enzymatic Assays to Explore Viral mRNA Capping Machinery (a review)
- 5) Development and validation of a rapid LC-MS/MS method for determination of methylated nucleosides and nucleobases in urine
- 6) Epigenetics: Roles and therapeutic implications of non-coding RNA modifications in human cancers (a review)
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