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CAS RN: 50-24-8 | 产品编码: P0637
Prednisolone
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| 产品编码 | P0637 |
纯度/分析方法 
|
>98.0%(HPLC) |
| 分子式/分子量 | C__2__1H__2__8O__5 = 360.45 |
| 外观与形状（20°C） | 固体 |
| 储存温度
|
室温 (15°C以下阴凉干燥处) |
| 包装和容器
|
1G-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 50-24-8 |
| Reaxys-RN | 1354103 |
| PubChem物质ID | 87574796 |
| SDBS (AIST Spectral DB) | 10998 |
| Merck Index (14) | 7721 |
| MDL编号 | MFCD00003649 |
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Specific rotation [a]20/D | +97.0 to +103.0 deg(C=1, Dioxane) |
| Solubility in Dioxane | almost transparency |
物性（参考值）
| 熔点 | 235 °C |
| 比旋光度 [α]D | 100° (C=1,Dioxane) |
| 水溶性 | 不溶 |
| 溶解性（可溶于） | 甲醇, 乙醇 |
| 溶解性（微溶于） | 二噁烷, 丙酮 |
| 溶解性（不溶于） | 乙醚 |
GHS
| 象形图 |
|
| 信号词 | Warning |
| 危险性说明 | H302 : Harmful if swallowed. H361 : Suspected of damaging fertility or the unborn child. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. P405 : Store locked up. |
相关法规
| RTECS# | TU4152000 |
运输信息
| HS编码* | 2937.21-000 |
应用
Bacterial spore germinant research
Bacterial spores are more resistant to antibiotics and nutritional deficiencies than their vegetative cells and sometimes cause serious problems from the viewpoint of hygiene in clinical treatment and food processing.1) Spore persistence also plays a major role in the recurrence of infections after antibiotic treatment. Molecules that stimulate germination are termed “germinants”1) and the efficacy of germinant administration combined with antibiotics have been evaluated (for example, reports by N. Budi et al.2,3)). Prednisolone has been reported to act as a germinant for Clostridium sordellii spores (EC50 = 17.9 μM).4)
(The product is for research purpose only.)
(The product is for research purpose only.)
References
- 1) Germinants and Their Receptors in Clostridia
- 2) Omadacycline Compared to Vancomycin When Combined with Germinants To Disrupt the Life Cycle of Clostridioides difficile.
- 3) Efficacy of Omadacycline or Vancomycin Combined With Germinants for Preventing Clostridioides difficile Relapse in a Murine Model
- 4) Progesterone Analogs Influence Germination of Clostridium sordellii and Clostriduim difficile Spores In Vitro
- Goodman and Gilman's The Pharmacological Basis of Therapeutics, Twelfth Edition
- Pharmacokinetics and pharmacodynamics of systemically administered glucocorticoids (a review)
- Glucocorticoid action and the development of selective glucocorticoid receptor ligands (a review)
- Allergic and pseudoallergic reactions induced by glucocorticoids: A review
- Simple liquid chromatography method for the rapid simultaneous determination of prednisolone and cortisol in plasma and urine using hydrophilic lipophilic balanced solid phase extraction cartridges
应用
Prednisolone: A Synthetic Adrenocortical Steroid Agent with Predominantly Glucocorticoid Properties
Prednisolone is a synthetic adrenocortical steroid agent with predominantly glucocorticoid properties, which is used for the treatment of a wide range of inflammatory and autoimmune conditions. It is the active hepatic metabolite of prednisone [P1276]. (The product is for research purpose only.)
References
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