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CAS RN: | 产品编码: P3244
Pyridostatin Pentatrifluoroacetate
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纯度/分析方法: >95.0%(HPLC)(qNMR)
别名：
- 吡啶抑素五三氟乙酸盐
- 4-(2-氨基乙氧基)-N2,N6-双[4-(2-氨基乙氧基)喹啉-2-基]吡啶-2,6-二甲酰胺五三氟乙酸盐
- 4-(2-氨基乙氧基)-N,N'-双[4-(2-氨基乙氧基)-2-喹啉基]-2,6-吡啶二甲酰胺五三氟乙酸盐
- 4-(2-Aminoethoxy)-N2,N6-bis[4-(2-aminoethoxy)quinolin-2-yl]pyridine-2,6-dicarboxamide Pentatrifluoroacetate
- 4-(2-Aminoethoxy)-N,N'-bis[4-(2-aminoethoxy)-2-quinolinyl]-2,6-pyridinedicarboxamide Pentatrifluoroacetate
产品文档：
| 产品编码 | P3244 |
纯度/分析方法 
|
>95.0%(HPLC)(qNMR) |
| 分子式/分子量 | C__3__1H__3__2N__8O__5·5C__2HF__3O__2 = 1,166.76 |
| 外观与形状（20°C） | 固体 |
| 储存温度
|
冷冻 (<0°C) |
| 储存在惰性气体下 | 存放于惰性气体之中 |
| 应避免的情况 | 湿气 (吸湿),加热 |
| 相关CAS RN
|
1085412-37-8&2758498-85-8 |
技术规格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Purity(qNMR) | min. 95.0 % |
| NMR | confirm to structure |
物性（参考值）
GHS
相关法规
运输信息
| HS编码* | 2933.49-000 |
应用
Pyridostatin Pentatrifluoroacetate: A Ligand for Stabilization of Guanine Quadruplexes in Cells
Guanine quadruplexes (G4s) are non-Watson-Crick four-stranded nucleic acid structures held together by noncanonical G-G base tetrads. Recent studies indicate their existence in vivo and their involvement in various biological processes.1) Pyridostatin pentatrifluoroacetate (RR82 pentatrifluoroacetate) stabilizes the G4s with high selectivity relative to double-stranded DNA and RNA, and can be used in to inhibit telomerase activity.2) Pyridostatin has been reported to promote growth arrest in human cancer cells by inducing replication- and transcription-dependent DNA damage.3-5) (The product is for research use only.)
References
- 1) G-quadruplex interacting small molecules and drugs: from bench toward bedside (a review)
- 2) A Novel Small Molecule That Alters Shelterin Integrity and Triggers a DNA-Damage Response at Telomeres
- 3) Small-molecule-induced DNA damage identifies alternative DNA structures in human genes
- 4) G-Quadruplex DNA as a Molecular Target for Induced Synthetic Lethality in Cancer Cells
- 5) Anti-tumoural activity of the G-quadruplex ligand pyridostatin against BRCA1/2-deficient tumours
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