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CAS RN: 166330-10-5 | 产品编码: R0301
DPEphos (HPMC encapsulated)
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Contents (per one capsule)
- DPEphos ca. 0.15 mmol
Uses of Reagent
- Applicable to palladium-catalyzed reactions due to a ligand encapsulated in HPMC capsules
Soluble Solvents
- Water, DMSO, DMF, 1,4-Dioxane (50°C), THF/Water mixture, 1,2-Dimethoxyethane/Water mixture
Related Product
- B2867 Bis[2-(diphenylphosphino)phenyl] Ether
| 产品编码 | R0301 |
| 分子式/分子量 | C__3__6H__2__8OP__2 = 538.57 |
| 外观与形状（20°C） | 固体 |
储存温度 
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室温 (15°C以下阴凉干燥处) |
| 储存在惰性气体下 | 存放于惰性气体之中 |
| 应避免的情况 | 湿气 (吸湿) |
| CAS RN | 166330-10-5 |
技术规格
| Appearance | White to Almost white capsule |
| Functionality test (conversion ratio) | min.90.0 % |
物性（参考值）
GHS
| 象形图 |
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| 信号词 | Warning |
| 危险性说明 | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| 防范说明 | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
相关法规
运输信息
| HS编码* | 3822.19-000 |
应用
TCI Practical Example: Suzuki-Miyaura Coupling Using the Encapsulated Pd2(dba)3 and DPEphos
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Used Chemicals
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Procedure
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Pd2(dba)3 (HPMC encapsulated) (one capsule) and DPEphos (HPMC encapsulated) (one capsule) were added to a solution of 2-acetamido-5-bromo-4-methylpyridine (340 mg, 1.50 mmol), cesium carbonate (540 mg, 2.0 mmol, 1.1 eq.) and phenylboronic acid (270 mg, 2.3 mmol, 1.5 eq.) in THF/water (10:1, 8.25 mL) at room temperature and the reaction mixture was stirred at 100 °C for 4 hours. The solution was then diluted with ethyl acetate (10 mL) and sat. sodium sulfate (10 mL), and filtered through Celite pad. The filtrate was separated and the organic layer was washed with water (15 mL) and brine (15 mL), dried over sodium sulfate and concentrated under reduced pressure. The crude product was purified by silica gel chromatography (ethyl acetate:hexane = 1:2 - 1:1) to afford 2-acetamido-4-methyl-5-phenylpyridine (319 mg, 94% yield) as a white solid.
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Experimenter’s Comments
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The reaction mixture was monitored by GC.
The material of the capsule is water-soluble HPMC (hydroxypropyl methylcellulose).
The shape of the capsule is like the image below and Pd2(dba)3 (ca. 60 μmol) and DPEphos (ca. 150 μmol) are encapsulated in each capsule, respectively.
The capsule disintegrates as shown in the image below when stirred in the solvent for about 15 minutes, releasing its content.
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Analytical Data
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2-Acetamido-4-methyl-5-phenylpyridine
1H NMR (400 MHz, CDCl3); δ 9.24-9.06 (brs, 1H), 8.16 (s, 1H), 8.10 (s, 1H), 7.46-7.36 (m, 3H), 7.30-7.29 (m, 2H), 2.32 (s, 3H), 2.21 (s, 3H).
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Lead Reference
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- Reagent and Catalyst Capsules: A Chemical Delivery System for Reaction Screening and Parallel Synthesis
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Other References
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- HPMC: A Biomass-Based Semisynthetic Sustainable Additive Enabling Clean and Fast Chemistry in Water
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![Bis[2-(diphenylphosphino)phenyl] Ether](/medias/Tci-300-B2867.jpg?context=bWFzdGVyfHJvb3R8MTUyNDF8aW1hZ2UvanBlZ3xhREJqTDJneE9DODVNemcyTnpnM05UWTVOamswTDFSamFTMHpNREJmUWpJNE5qY3VhbkJufGE0ZDY0NWExYzQwODYwMDE1ZGY1YmY2ZWM4YTI4NGVhMGI2NWJiMjBlNjNhNzgxMTczMmZiOWMxOGRmOGVhMmI "Bis[2-(diphenylphosphino)phenyl] Ether")