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CAS RN: 22722-98-1 | 产品编码: S0467
Sodium Bis(2-methoxyethoxy)aluminum Dihydride (70% in Toluene, ca. 3.6mol/L)
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补充产品信息:
Both 100g and 500g bottles of this product are attached with a DualSeal (Septum-type Bottle Cap).
For details, please refer to the page "DualSeal (Septum-type Bottle Cap)".
| 产品编码 | S0467 |
| 分子式/分子量 | C__6H__1__6AlNaO__4 = 202.16 |
| 外观与形状（20°C） | 液体 |
储存温度 
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室温 (15°C以下阴凉干燥处) |
| 储存在惰性气体下 | 存放于惰性气体之中 |
| 应避免的情况 | 光,湿气 (分解) |
| 包装和容器
|
100G-DualSeal Bottle （查看图片）, 500G-DualSeal Bottle （查看图片） |
| CAS RN | 22722-98-1 |
| PubChem物质ID | 87575946 |
| MDL编号 | MFCD00011631 |
技术规格
| Appearance | Colorless to Almost colorless clear liquid |
| Concentration(NBS Method) | 68.0 to 77.0 w/w% |
物性（参考值）
| 闪点 | 4 °C |
| 比重 | 1.02 |
GHS
| 象形图 |
|
| 信号词 | Danger |
| 危险性说明 | H314 : Causes severe skin burns and eye damage. H360 : May damage fertility or the unborn child. H370 : Causes damage to organs. H372 : Causes damage to organs through prolonged or repeated exposure. H335 : May cause respiratory irritation. H304 : May be fatal if swallowed and enters airways. H401 : Toxic to aquatic life. H225 : Highly flammable liquid and vapor. H260 : In contact with water releases flammable gases which may ignite spontaneously. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P223 : Do not allow contact with water. P273 : Avoid release to the environment. P270 : Do not eat, drink or smoke when using this product. P202 : Do not handle until all safety precautions have been read and understood. P240 : Ground and bond container and receiving equipment. P231 + P232 : Handle and store contents under inert gas. Protect from moisture. P260 : Do not breathe mist or vapours. P210 : Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking. P233 : Keep container tightly closed. P201 : Obtain special instructions before use. P243 : Take action to prevent static discharges. P241 : Use explosion-proof electrical/ ventilating/ lighting/ equipment. P242 : Use non-sparking tools. P271 : Use only outdoors or in a well-ventilated area. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P370 + P378 : In case of fire: Use dry sand, dry chemical or alcohol-resistant foam to extinguish. P308 + P311 : IF exposed or concerned: Call a POISON CENTER/doctor. P303 + P361 + P353 : IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water. P302 + P335 + P334 : IF ON SKIN: Brush off loose particles from skin. Immerse in cool water. P301 + P310 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. P301 + P330 + P331 : IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P363 : Wash contaminated clothing before reuse. P304 + P340 + P310 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Immediately call a POISON CENTER/doctor. P305 + P351 + P338 + P310 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER/doctor. P403 + P233 : Store in a well-ventilated place. Keep container tightly closed. P402 + P404 : Store in a dry place. Store in a closed container. P403 + P235 : Store in a well-ventilated place. Keep cool. P405 : Store locked up. |
相关法规
运输信息
| UN编号 | UN3399 |
| 类别 | 4.3 / 3 |
| 包装类别 | I |
| HS编码* | 2931.90-000 |
应用
TCI Practical Example: Z-Selective Hydroiodination of Propargyl Alcohol
Used Chemicals
Procedure
To a reaction vessel tetrahydrofuran (40 mL) was added and cooled with an ice bath. Sodium bis(2-methoxyethoxy)aluminum dihydride (70% in Toluene, ca. 3.6 mol/L) (7.0 mL, 25.0 mmol) and 3-phenyl-2-propyn-1-ol (2.0 g, 15 mmol) diluted in tetrahydrofuran (10 mL) were subsequently added dropwise, and the reaction mixture was stirred at room temperature for 2 hours. The reaction was monitored by TLC and confirmed the starting material was completely consumed, then the reaction mixture cooled in an ice bath. Ethyl acetate (5 mL) was added dropwise to quench and stirred for 30 minutes. The reaction mixture was cooled to -78 °C and iodine (7.5 g, 30 mmol) was added in one portion, then warmed to 0 °C and stirred for 1 hour. The reaction was quenched with respectively saturated aqueous Rochelle salt solution (50 mL) and saturated aqueous sodium thiosulfate solution (50 mL). The aqueous layer was extracted with ethyl acetate and the organic layer was washed with saturated aqueous sodium thiosulfate solution and brine, then dried over magnesium sulfate and filtered. The filtrate was concentrated to obtain crude product. Purification by silica gel column chromatography (hexane:ethyl acetate = 6:1) gave (Z)-3-Iodo-3-phenyl-2-propen-1-ol (2.2 g, 56% yield) as a yellow oil.
Experimenter’s Comments
The reaction mixture was monitored by TLC (hexane:ethyl acetate = 4:1, Rf = 0.6).
Analytical Data
1H NMR (400 MHz, CDCl3); δ 7.50-7.45 (m, 2H), 7.35-7.27 (m, 3H), 6.26 (t, 1H, J = 5.9 Hz), 4.40 (d, 2H, J = 5.9 Hz), 1.80 (br, 1H).
Lead Reference
- Stereoselective Lewis Acid Mediated [1,3] Ring Contraction of 2,5-Dihydrooxepins as a Route to Polysubstituted Cyclopentenes
Other Reference
- Total Synthesis and Biological Evaluation of the Cytotoxic Resin Glycosides Ipomoeassin A–F and Analogues
参考文献
Please visit the Pubchem page at this link.
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