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CAS RN: 60239-18-1 | 产品编码: T1875
1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic Acid
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| 产品编码 | T1875 |
| 纯度/分析方法 | >97.0%(T) |
| 分子式/分子量 | C__1__6H__2__8N__4O__8 = 404.42 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 室温 (15°C以下阴凉干燥处) |
| 储存在惰性气体下 | 存放于惰性气体之中 |
| 应避免的情况 | 空气 |
| 包装和容器 | 1G-Glass Bottle with Plastic Insert （查看图片）, 200MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 60239-18-1 |
| Reaxys-RN | 1186987 |
| PubChem物质ID | 87560717 |
| MDL编号 | MFCD00068657 |
技术规格
| Appearance | White to Almost white powder to crystaline |
| Purity(Chelometric Titration) | min. 97.0 % |
物性（参考值）
| 熔点 | 267 °C |
GHS
| 象形图 |
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| 信号词 | Warning |
| 危险性说明 | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| 防范说明 | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
相关法规
运输信息
| HS编码* | 2933.99-000 |
应用
The Reviews of DOTA: One of the Preeminent Carriers of Metal-Based Imaging Contrast Agents for Biomedical Imaging.
1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) is one of the preeminent carriers of metal-based imaging contrast agents. Metal complexes of DOTA-peptide or others conjugates have increasingly used in Magnetic Resonance Imaging (MRI), Positron Emission Tomography (PET), Single Photon Emission Computed Tomography (SPECT) and Fluorescence imaging.
References
- The Synthesis and Chelation Chemistry of DOTA-Peptide Conjugates
- PET (positron emission tomography) imaging of biomolecules using metal-DOTA complexes: a new collaborative challenge by chemists, biologists, and physicians for future diagnostics and exploration of in vivo dynamics
- 64Cu-labeled tetrameric and octameric RGD peptides for small-animal PET of tumor αvβ3 integrin expression
- The coordination chemistry of 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetic acid (H4DOTA): Structural overview and analyses on structure-stability relationships
- The ubiquitous DOTA and its derivatives: the impact of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid on biomedical imaging
参考文献