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CAS RN: 181934-29-2 | 产品编码: T3272
1-[(Trimethylsilyl)ethynyl]-1,2-benziodoxol-3(1H)-one
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| 产品编码 | T3272 |
纯度/分析方法 
|
>98.0%(T) |
| 分子式/分子量 | C__1__2H__1__3IO__2Si = 344.22 |
| 外观与形状（20°C） | 固体 |
| 储存温度
|
冷藏 (0-10°C) |
| 储存在惰性气体下 | 存放于惰性气体之中 |
| 应避免的情况 | 光,空气,加热 |
| 包装和容器
|
1G-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 181934-29-2 |
| Reaxys-RN | 7707098 |
| PubChem物质ID | 354333836 |
技术规格
| Appearance | White to Light yellow to Light orange powder to crystal |
| Purity(Precipitation Titration) | min. 98.0 % |
物性（参考值）
| 熔点 | 140 °C(dec.) |
GHS
| 象形图 |
|
| 信号词 | Warning |
| 危险性说明 | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| 防范说明 | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
相关法规
运输信息
| HS编码* | 2934.99-000 |
应用
An Ethynylating Agent
Experimental procedure1): A solution of 1 (89 mg, 0.40 mmol, 1.0 eq.) and TMS-EBX (179 mg, 0.520 mmol, 1.3 eq.) in dried THF (6 mL) is stirred at -78 °C for 5 min under nitrogen. After this period of time, TBAF (1 mol/L in THF, 1.3 eq.) is added and mixture is vigorously stirred for 1 h at -78 °C. The reaction mixture is quenched with deactivated silica gel and the solvent is evaporated under reduced pressure. The product is purified by flash chromatography (SiO2, Hexane:EtOAc = 8:1) to afford 2 (92 mg, 0.37 mmol, 93%) as yellow oil.
References
- 1)Ethynyl-1,2-benziodoxol-3(1H)-one (EBX): An Exceptional Reagent for the Ethynylation of Keto, Cyano, and Nitro Esters
- 2)A Highly Chemoselective and Practical Alkynylation of Thiols
参考文献