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CAS RN: 10537-47-0 | 产品编码: T3667
Tyrphostin A9
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| 产品编码 | T3667 |
纯度/分析方法 
|
>98.0%(GC) |
| 分子式/分子量 | C__1__8H__2__2N__2O = 282.39 |
| 外观与形状（20°C） | 固体 |
| 储存温度
|
室温 (15°C以下阴凉干燥处) |
| 包装和容器
|
25MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 10537-47-0 |
| Reaxys-RN | 2700764 |
| PubChem物质ID | 468592884 |
| MDL编号 | MFCD00209853 |
技术规格
| Appearance | Light orange to Yellow to Green powder to crystal |
| Purity(GC) | min. 98.0 % |
| Melting point | 139.0 to 147.0 °C |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 140 °C |
| 最大吸收波长 | 464 nm (EtOH) |
GHS
| 象形图 |
|
| 信号词 | Danger |
| 危险性说明 | H301 + H311 + H331 : Toxic if swallowed, in contact with skin or if inhaled. H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P261 : Avoid breathing dust/ fume/ gas/ mist/ vapors/ spray. P270 : Do not eat, drink or smoke when using this product. P271 : Use only outdoors or in a well-ventilated area. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P361 + P364 : Take off immediately all contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P302 + P352 + P312 : IF ON SKIN: Wash with plenty of water.Call a POISON CENTER/doctor if you feel unwell. P304 + P340 + P311 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Call a POISON CENTER/doctor. P403 + P233 : Store in a well-ventilated place. Keep container tightly closed. P405 : Store locked up. |
相关法规
| RTECS# | OO3737000 |
运输信息
| UN编号 | UN3439 |
| 类别 | 6.1 |
| 包装类别 | III |
| HS编码* | 2926.90-000 |
应用
Type IV secretion system (T4SS) research
Reference
- Chemical Genetics Reveals Bacterial and Host Cell Functions Critical for Type IV Effector Translocation by Legionella pneumophila
应用
Tyrphostin A9: A Tyrosine Kinase Inhibitor
Tyrphostin A9 (other names in the references: Malonoben, Tyrphostin AG17 or SF6847) is a tyrosine kinase inhibitor originally synthesized as a potential anticarcinogenic compound. Reportedly, tyrphostin A9 selectively inhibits the activity of a platelet-derived growth factor receptor (PDGFR) protein1), the growth of vascular smooth muscle cells1), the growth of cancer cells2,3), and the phosphorylation of tyrosine1,2,4,5).
References
- 1)Tyrphostins inhibit PDGF-induced DNA synthesis and associated early events in smooth muscle cells
- 2)STAT3 is essential for Hodgkin lymphoma cell proliferation and is a target of tyrphostin AG17 which confers sensitization for apoptosis
- 3)Tyrphostin AG17, [(3,5-Di-tert-butyl-4-hydroxybenzylidene)-malononitrile], inhibits cell growth by disrupting mitochondria
- 4)Role of the tyrosine kinase pyk2 in the integrin-dependent activation of human neutrophils by TNF
- 5)Tyrphostin A9 inhibits calcium release-dependent phosphorylations and calcium entry via calcium release-activated channel in Jurkat T cells
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