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CAS RN: 124832-27-5 | 产品编码: V0111
Valacyclovir Hydrochloride
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This product is a sample for RUO (research use only). Do not use this product for any purpose other than testing and research.
| 产品编码 | V0111 |
纯度/分析方法 
|
>97.0%(HPLC)(N) |
| 分子式/分子量 | C__1__3H__2__0N__6O__4·HCl = 360.80 |
| 外观与形状（20°C） | 固体 |
| 储存温度
|
室温 (15°C以下阴凉干燥处) |
| 包装和容器
|
100MG-Glass Bottle with Plastic Insert （查看图片）, 1G-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 124832-27-5 |
| 相关CAS RN
|
124832-26-4&1218948-84-5 |
| Reaxys-RN | 14243859 |
| PubChem物质ID | 125307930 |
| SDBS (AIST Spectral DB) | 52990 |
| Merck Index (14) | 9899 |
| MDL编号 | MFCD01861507 |
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 97.0 area% |
| Purity(with Total Nitrogen) | min. 97.0 %(calcd.on anh.substance) |
| Water | max. 6.0 % |
物性（参考值）
| 最大吸收波长 | 253 nm (H__2O) |
| 水溶性 | 可溶 |
GHS
| 象形图 |
|
| 信号词 | Warning |
| 危险性说明 | H302 : Harmful if swallowed. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
相关法规
运输信息
| HS编码* | 2933.99-000 |
应用
Valacyclovir Hydrochloride: A Prodrug of Antiviral Acyclovir
Valacyclovir hydrochloride is a prodrug of antiviral acyclovir [A1915] which is a nucleoside analog DNA polymerase inhibitor. It was developed to improve the pharmacokinetic characteristics of acyclovir. After oral administration, valacyclovir hydrochloride is rapidly absorbed from the gastrointestinal tract by the intestinal peptide transporter (PEPT1) and converted to acyclovir and L-valine [V0014] by first-pass intestinal and/or hepatic metabolism. (The product is for research purpose only.)
References
- Amino acid ester prodrugs of acyclovir
- Direct evidence for peptide transporter (PepT1)-mediated uptake of a nonpeptide prodrug, valacyclovir
- Valacyclovir: a substrate for the intestinal and renal peptide transporters PEPT1 and PEPT2
- Valacyclovir: a review of its antiviral activity, pharmacokinetic properties, and clinical efficacy (a review)
- Valaciclovir: A review of its antiviral activity, pharmacokinetic properties and therapeutic efficacy in herpesvirus infections (a review)
- New drugs - reports of new drugs recently approved by the FDA. Valacyclovir (a review)
PubMed Literature
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