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CAS RN: 184475-35-2 | Product Number: G0546

Gefitinib


Purity: >98.0%(T)(HPLC)
Synonyms:
  • N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholinopropoxy)quinazolin-4-amine
Documents:
1G
$74.00
31   ≥40 
5G
$255.00
≥40  Contact Us

* Please contact our distributors or TCI to order our products. The above prices do not include freight cost, customs, and other charges to the destination.
* The storage conditions are subject to change without notice.


Product Number G0546
Purity / Analysis Method >98.0%(T)(HPLC)
Molecular Formula / Molecular Weight C__2__2H__2__4ClFN__4O__3 = 446.91 
Physical State (20 deg.C) Solid
Storage Temperature 0-10°C
Condition to Avoid Heat Sensitive
Packaging and Container 1G-Glass Bottle with Plastic Insert (View image)
CAS RN 184475-35-2
Reaxys Registry Number 8949523
PubChem Substance ID 468591928
MDL Number

MFCD04307832

Specifications
Appearance White to Light yellow powder to crystal
Purity(HPLC) min. 98.0 area%
Purity(Nonaqueous Titration) min. 98.0 %
Melting point 194.0 to 198.0 °C
Properties (reference)
Melting Point 196 °C
Maximum Absorption Wavelength 332 nm
Solubility in water Insoluble
Solubility (slightly sol. in) Tetrahydrofuran
Solubility (very slightly) Methanol,Ethanol
GHS
Pictogram Pictogram Pictogram
Signal Word Warning
Hazard Statements H302 : Harmful if swallowed.
H315 : Causes skin irritation.
H319 : Causes serious eye irritation.
H361 : Suspected of damaging fertility or the unborn child.
H373 : May cause damage to organs through prolonged or repeated exposure.
H351 : Suspected of causing cancer.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P260 : Do not breathe dust/ fume/ gas/ mist/ vapors/ spray.
P270 : Do not eat, drink or smoke when using this product.
P202 : Do not handle until all safety precautions have been read and understood.
P201 : Obtain special instructions before use.
P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection.
P302 + P352 : IF ON SKIN: Wash with plenty of water.
P308 + P313 : IF exposed or concerned: Get medical advice/ attention.
P337 + P313 : If eye irritation persists: Get medical advice/ attention.
P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P362 + P364 : Take off contaminated clothing and wash it before reuse.
P332 + P313 : If skin irritation occurs: Get medical advice/ attention.
P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth.
P405 : Store locked up.
Related Laws:
RTECS# VA0952000
Transport Information:
H.S.code* 2934.99-000
*This code is applied to the products when TCI exports from Japan and not for import in your country.
Application
Gefitinib: A Potent and Selective Inhibitor of EGFR Tyrosine Kinase

The epidermal growth factor receptor (EGFR), a receptor tyrosine kinase (RTK), is expressed on the cell surface of both normal and cancer cells and plays a role in the processes of cell growth and proliferation. It is reported that gefitinib (ZD1839) is a potent and selective inhibitor of EGFR tyrosine kinase (EGFRTK). In vitro, gefitinib arrests the cell cycle at G1 phase by inducing intrinsic cyclin-dependent kinase (cdk) inhibitors. Furthermore, gefitinib inhibits vascular endothelial growth factor (VEGF) production in tumor cells through inhibition of EGFR signaling, leading to suppression of angiogenesis. For your reference, [C3647] and [H1606] are key synthetic intermediates of gefitinib. (The product is for research purpose only.)

References


TCIMAIL
Documents (Note: Some products will not have analytical charts available.)
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