Published TCIMAIL newest issue No.201
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Phospholipids (for DDS)
Phospholipids are phosphoric acid esters of fatty acid, which are major components of all cell membranes. It is well known that the thin polar membrane is made of two phospholipid layers (lipid bilayers) due to the amphiphilic property. As an example of lipid bilayer, liposomes have capsule structure which can contain small amounts of other molecules. Liposomes consisting of phospholipids such as DMPC (Product No. D3924), DSPE (Product No. D4214) and DOPG Sodium Salt (Product No. D5318) can be applied to controlled release dosage, drug delivery systems, and cosmetics.1)
PEG-modified phospholipids such as Methly-PEG2000-DSPE (Product No. M3264) have been developed to improve the retention of liposomes in blood,2) and charge-reversible phospholipids such as DOP-DEDA (Product No. D6219) have enabled nucleic acid delivery via liposomes.3)
We also offer high-purity cholesterol (>99%) (Product No. C3624) which is used in the preparation of liposomes.
References
- 1) a) Liposomes, Methods and Protocols, Volume 1: Pharmaceutical Nanocarriers, ed. by V. Weissig, Humana Press, 2010.
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- c) A review on phospholipids and their main applications in drug delivery systems
- 2) a) Stealth liposomes: review of the basic science, rationale, and clinical applications, existing and potential
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- b) Surface Engineering of Liposomes for Stealth Behavior
- 3) Charge-reversible lipid derivative: A novel type of pH-responsive lipid for nanoparticle-mediated siRNA delivery
| Product Number | D3925 |
| CAS RN | 63-89-8 |
| Purity / Analysis Method: | >98.0%(HPLC) |
| Product Number | D3946 |
| CAS RN | 200880-40-6 |
| Purity / Analysis Method: | >98.0%(T) |
| Product Number | D4251 |
| CAS RN | 4004-05-1 |
| Purity / Analysis Method: | >98.0%(T) |
| Product Number | D5318 |
| CAS RN | 67254-28-8 |
| Purity / Analysis Method: | >98.0%(T) |
| Product Number | D5648 |
| CAS RN | 200880-42-8 |
| Purity / Analysis Method: | >98.0%(HPLC) |
| Product Number | P2522 |
| CAS RN | 268550-95-4 |
| Purity / Analysis Method: | >98.0%(T) |
| Product Number | P2694 |
| CAS RN | 17364-16-8 |
| Purity / Analysis Method: | >98.0%(T)(HPLC) |
| Product Number | T3808 |
| CAS RN | 19420-57-6 |
| Purity / Analysis Method: | >98.0%(T)(HPLC) |
| Product Number | D3924 |
| CAS RN | 18194-24-6 |
| Purity / Analysis Method: | >97.0%(T)(HPLC) |
| Product Number | D4214 |
| CAS RN | 1069-79-0 |
| Purity / Analysis Method: | >97.0%(HPLC)(N) |
| Product Number | D4249 |
| CAS RN | 998-07-2 |
| Purity / Analysis Method: | >97.0%(T)(HPLC) |
Product Number: D3925Purity / Analysis Method:
>98.0%(HPLC)
Product Number: D3946Purity / Analysis Method:
>98.0%(T)
Product Number: D4251Purity / Analysis Method:
>98.0%(T)
Product Number: D5318Purity / Analysis Method:
>98.0%(T)
Product Number: D5648Purity / Analysis Method:
>98.0%(HPLC)
Product Number: P2522Purity / Analysis Method:
>98.0%(T)
Product Number: P2694Purity / Analysis Method:
>98.0%(T)(HPLC)
Product Number: T3808Purity / Analysis Method:
>98.0%(T)(HPLC)
Product Number: D3924Purity / Analysis Method:
>97.0%(T)(HPLC)
Product Number: D4214Purity / Analysis Method:
>97.0%(HPLC)(N)
Product Number: D4249Purity / Analysis Method:
>97.0%(T)(HPLC)
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