Phospholipids (for DDS)

Phospholipids are phosphoric acid esters of fatty acid, which are major components of all cell membranes. It is well known that the thin polar membrane is made of two phospholipid layers (lipid bilayers) due to the amphiphilic property. As an example of lipid bilayer, liposomes have capsule structure which can contain small amounts of other molecules. Liposomes consisting of phospholipids such as DMPC [D3924], DSPE [D4214] and DOPG Sodium Salt [D5318] can be applied to controlled release dosage, drug delivery systems, and cosmetics.¹⁾

PEG-modified phospholipids such as Methly-PEG2000-DSPE [M3264] have been developed to improve the retention of liposomes in blood,²⁾ and charge-reversible phospholipids such as DOP-DEDA [D5882] have enabled nucleic acid delivery via liposomes.³⁾

We also offer high-purity cholesterol (>99%) [C3624] which is used in the preparation of liposomes.

References

• 1) a) Liposomes, Methods and Protocols, Volume 1: Pharmaceutical Nanocarriers, ed. by V. Weissig, Humana Press, 2010.
• • b) Liposomes, Methods and Protocols, ed. by G. G.M. D'Souza, Humana Press, 2017.
• • c) A review on phospholipids and their main applications in drug delivery systems
    • J. Li, X. Wang, T. Zhang, C. Wang, Z. Huang, X. Luo, Y. Deng, Asian J. Pharm. Sci. 2015, 10, 81.
• 2) a) Stealth liposomes: review of the basic science, rationale, and clinical applications, existing and potential
  • • M. L. Immordino, F. Dosio, L. Cattel, Int. J. Nanomedicine 2006, 1, 297.
• • b) Surface Engineering of Liposomes for Stealth Behavior
    • O. K. Nag, V. Awasthi, Pharmaceutics 2013, 5, 542.
• 3) Charge-reversible lipid derivative: A novel type of pH-responsive lipid for nanoparticle-mediated siRNA delivery
  • Y. Hirai, R. Saeki, F. Song, H. Koide, N. Fukata, K. Tomita, N. Maeda, N. Oku, T. Asai, Int. J. Pharm. 2020, 585, 119479.

Related Product Category Page

• Drug Delivery Systems (DDS)