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Published TCIMAIL newest issue No.198
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CAS RN: 69304-47-8 | Product Number: B3404
(E)-5-(2-Bromovinyl)-2'-deoxyuridine
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Purity: >98.0%(T)(HPLC)
Synonyms:
- Brivudine
- BVdU
Product Documents:
| Size | Unit Price | Belgium | Japan* |
|---|---|---|---|
| 100MG |
€114.00
|
Contact Us | 20 |
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
Supplemental Product Information:
This product is a sample for RUO (research use only). Do not use this product for any purpose other than testing and research.
| Product Number | B3404 |
Purity / Analysis Method 
|
>98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__1H__1__3BrN__2O__5 = 333.14 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| Packaging and Container
|
100MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 69304-47-8 |
| Reaxys Registry Number | 758153 |
| PubChem Substance ID | 87561214 |
| Merck Index (14) | 1378 |
| MDL Number | MFCD00058585 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
| Specific rotation [a]20/D | +8.0 to +10.0 deg(C=1, MeOH) |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 166 °C(dec.) |
| Specific Rotation | 9° (C=1,MeOH) |
GHS
Related Laws:
| RTECS# | YU7355000 |
Transport Information:
| HS Number | 2934999090 |
Application
Brivudine (BVdU): A Nucleoside Analogue Anti-Herpesvirus Agent
Brivudine (BVdU) is a nucleoside analogue anti-herpesvirus agent, and is often used for treatment of herpes simplex virus-1 (HSV-1) and varicella-zoster virus (VZV) infections. Brivudine blocks the action of DNA polymerases, thus inhibiting viral replication. Brivudine owes its effect to preferential phosphorylation by virus-encoded thymidine kinase to its 5'-diphosphate form. After further conversion to triphosphate form, it acts as an inhibitor or alternate substrate for the viral DNA polymerase. Brivudine is also characterized by a well described fatal drug interaction with antitumor agents such as 5-fluorouracil (5-FU) [F0151] and its prodrugs. This is caused by the main metabolite, bromovinyluracil (BVU), irreversibly inhibiting the enzyme dihydropyrimidine dehydrogenase (DPD) which is necessary for inactivating 5-FU. (The product is for research purpose only.)
References
- (E)-5-(2-Bromovinyl)-2'-deoxyuridine: a potent and selective anti-herpes agent
- On the mechanism of selective inhibition of herpesvirus replication by (E)-5-(2-bromovinyl)-2'-deoxyuridine
- Discovery and development of BVDU (brivudine) as a therapeutic for the treatment of herpes zoster (a review)
- (E)-5-(2-Bromovinyl)-2'-deoxyuridine (BVDU) (a review)
PubMed Literature
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