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CAS RN: 53-85-0 | Product Number: D4292
5,6-Dichlorobenzimidazole 1-β-D-Ribofuranoside
×
Purity: >98.0%(HPLC)(qNMR)
Synonyms:
- 5,6-Dichlorobenzimidazole Riboside
- 5,6-Dichloro-1-(β-D-ribofuranosyl)benzimidazole
- DRB
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 100MG |
NT$5,175
|
6 | 0 | It can be shipped in about 2 weeks after ordering | |
| 1G |
NT$26,955
|
2 | 14 | It can be shipped in about 2 weeks after ordering |
* The above prices include freight cost, customs, and other charges to the destination except for products that need to be shipped by sea or dry ice. For details, please contact
our distributor
in Taiwan to order our product.
* The storage conditions are subject to change without notice.
| Product Number | D4292 |
Purity / Analysis Method 
|
>98.0%(HPLC)(qNMR) |
| Molecular Formula / Molecular Weight | C__1__2H__1__2Cl__2N__2O__4 = 319.14 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Frozen (<0°C) |
| Condition to Avoid | Heat Sensitive |
| Packaging and Container
|
100MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 53-85-0 |
| Reaxys Registry Number | 39123 |
| PubChem Substance ID | 253660379 |
| MDL Number | MFCD00036785 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(qNMR) | min. 98.0 % |
| Melting point | 220.0 to 224.0 °C |
| Specific rotation [a]20/D | -66.0 ～ -68.0 deg(C=2, Pyridine) |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 222 °C |
| Specific Rotation | -67° (C=2,Pyridine) |
| Maximum Absorption Wavelength | 296 nm |
GHS
Related Laws:
| RTECS# | DD7310000 |
Transport Information:
| H.S.code* | 2934.99-000 |
Application
5,6-Dichlorobenzimidazole 1-β-D-ribofuranoside (DRB): A Selective Inhibitor of Transcription Elongation by RNA Polymerase II
5,6-Dichlorobenzimidazole 1-β-D-ribofuranoside (DRB) is a selective inhibitor of transcription elongation by RNA polymerase II, and then it inhibits of mRNA synthesis in eukaryotic cells. The inhibition can trigger p53-dependent apotosis of tumor cells. DRB can also inhibit HIV transcription by targeting elongation enhanced by the HIV-encoded transactivator (Tat).
References
- 5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole inhibits transcription elongation by RNA polymerase II in vitro
- The transcriptional elongation inhibitor 5,6-dichloro-1-β-D-ribofuranosylbenzimidazole inhibits transcription factor IIH-associated protein kinase
- Inhibition of RNA polymerase II as a trigger for the p53 response
- DSIF and NELF interact with RNA polymerase II elongation complex and HIV-1 Tat stimulates P-TEFb-mediated phosphorylation of RNA polymerase II and DSIF during transcription elongation
- Halogen Bonds Form the Basis for Selective P-TEFb Inhibition by DRB
PubMed Literature
Product Articles
[TCIMAIL No.164] DRB : A Selective Inhibitor of Transcription Elongation by RNA Polymerase II
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