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CAS RN: | Product Number: P3244
Pyridostatin Pentatrifluoroacetate
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Purity: >95.0%(HPLC)(qNMR)
Synonyms:
- 4-(2-Aminoethoxy)-N2,N6-bis[4-(2-aminoethoxy)quinolin-2-yl]pyridine-2,6-dicarboxamide Pentatrifluoroacetate
- 4-(2-Aminoethoxy)-N,N'-bis[4-(2-aminoethoxy)-2-quinolinyl]-2,6-pyridinedicarboxamide Pentatrifluoroacetate
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 5MG |
NT$3,822
|
≥40 | 0 | Contact Us | |
| 25MG |
NT$13,398
|
≥60 | 0 | Contact Us |
* The above prices include freight cost, customs, and other charges to the destination except for products that need to be shipped by sea or dry ice. For details, please contact
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* The storage conditions are subject to change without notice.
| Product Number | P3244 |
Purity / Analysis Method 
|
>95.0%(HPLC)(qNMR) |
| Molecular Formula / Molecular Weight | C__3__1H__3__2N__8O__5·5C__2HF__3O__2 = 1,166.76 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Frozen (<0°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Hygroscopic,Heat Sensitive |
| Related CAS RN
|
1085412-37-8&2758498-85-8 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Purity(qNMR) | min. 95.0 % |
| NMR | confirm to structure |
Properties (reference)
GHS
Related Laws:
Transport Information:
| H.S.code* | 2933.49-000 |
Application
Pyridostatin Pentatrifluoroacetate: A Ligand for Stabilization of Guanine Quadruplexes in Cells
Guanine quadruplexes (G4s) are non-Watson-Crick four-stranded nucleic acid structures held together by noncanonical G-G base tetrads. Recent studies indicate their existence in vivo and their involvement in various biological processes.1) Pyridostatin pentatrifluoroacetate (RR82 pentatrifluoroacetate) stabilizes the G4s with high selectivity relative to double-stranded DNA and RNA, and can be used in to inhibit telomerase activity.2) Pyridostatin has been reported to promote growth arrest in human cancer cells by inducing replication- and transcription-dependent DNA damage.3-5) (The product is for research use only.)
References
- 1) G-quadruplex interacting small molecules and drugs: from bench toward bedside (a review)
- 2) A Novel Small Molecule That Alters Shelterin Integrity and Triggers a DNA-Damage Response at Telomeres
- 3) Small-molecule-induced DNA damage identifies alternative DNA structures in human genes
- 4) G-Quadruplex DNA as a Molecular Target for Induced Synthetic Lethality in Cancer Cells
- 5) Anti-tumoural activity of the G-quadruplex ligand pyridostatin against BRCA1/2-deficient tumours
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