TCI Chemistry News
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August 2022
TCI offers an extensive catalog of 31,000 high-quality organic reagents suitable for benchtop-to-bulk chemistry. This issue covers our chemistry topics as follows:
- New Reagent for Synthesis of Primary Sulfonamides: tBuONSO
- Pseudouridines: Key Component of mRNA Medicine
- C-H Arylation of N-Heteroarene Using a Photoredox Catalyst
- One-Pot Palladium-Catalyzed Fluorosulfonylation of an Aryl Bromide Using DABSO and NFSI
New Reagent for Synthesis of Primary Sulfonamides: tBuONSO
In the field of medicinal chemistry, sulfonamide moiety is a common substructure and plays an important role for biological activity. Sulfonamides can be utilized as bioisosteres of carboxylic acids owing to their structural similarity and an acidic proton. tBuONSO [U0150] has been reported to undergo nucleophilic attack by Grignard reagents and organolithium reagents to give primary sulfonamides. This method is widely applicable to a variety of substrates like tertiary amines and hetero aromatic compounds, which are sensitive to oxidative conditions.
Pseudouridines: Key Component of mRNA Medicine
Recently, mRNA medicines that generate specific proteins in target cells have received a lot of attention. Application of mRNA medicines are expected for not only vaccine but also protein replacement therapy, regenerative medicine, and gene-editing therapy by expression antigens, enzymes, signal proteins and more. In translation of mRNA into protein in target cell, 1-methylpseudouridine (m1Ψ) [M3387] and pseudouridine (Ψ) [P2939] are read like uridine (U), enhancing immune evasion and protein production. TCI offers 1-methylpseudouridine and pseudouridine by chemical synthesis, and can also supply these products in bulk quantities or synthesize the derivatives.
TCI Practical Example: C-H Arylation of N-Heteroarene Using a Photoredox Catalyst
We are proud to present the C-H arylation of caffeine with 4-methoxybenzenediazonium tetrafluoroborate by using tris(2,2'-bipyridyl)ruthenium(II) chloride hexahydrate [T1655] as a photoredox catalyst. TCI has many visible light photoredox catalysts for photoreaction.
TCI Practical Example: One-Pot Palladium-Catalyzed Fluorosulfonylation of an Aryl Bromide Using DABSO and NFSI
TCI introduces the synthetic protocol of 4-biphenylsulfonyl fluoride from 4-bromobiphenyl using DABSO [B3960] , NFSI [F0335] as reactants, and PdCl 2 (Amphos) 2 [B6255] as a palladium catalyst. You can see the other reaction examples using DABSO in TCI product brochure . » TCI eNewsletter Back IssuesFollow Us on Social Media
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