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CAS RN: 549-18-8 | 產品號碼: A0908
Amitriptyline Hydrochloride
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產品號碼 | A0908 |
純度/分析方法 | >98.0%(T)(HPLC) |
分子式 / 分子量 | C__2__0H__2__3N·HCl = 313.87 |
外觀與形狀(20°C) | Solid |
儲存條件 | Room Temperature (Recommended in a cool and dark place, <15°C) |
應避免的情況 | Light Sensitive |
CAS RN | 549-18-8 |
相關CAS RN | 50-48-6 |
Reaxys-RN | 4164595 |
PubChem Substance ID | 87562417 |
Merck Index(14) | 487 |
MDL編號 | MFCD00012537 |
產品規格
Appearance | White to Almost white powder to crystal |
Purity(HPLC) | min. 98.0 area% |
Purity(Nonaqueous Titration) | min. 98.0 % |
Melting point | 195.0 to 199.0 °C |
Solubility in Water | almost transparency |
NMR | confirm to structure |
性質
熔點 | 195 °C |
水溶性 | Soluble |
GHS
圖形表示 |
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信號詞 | Danger |
危險性說明 | H301 : Toxic if swallowed. H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
防範說明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
相關法規
RTECS # | HO9450000 |
運輸資料
UN編號 | UN2811 |
類別 | 6.1 |
包裝類別 | III |
HS編碼* | 2921.49-000 |
Application
Amitriptyline Hydrochloride: An Inhibitor of Serotonin or Noradrenaline Re-Uptake Transporters
Amitriptyline hydrochloride is the most widely used tricyclic antidepressant agent with sedative effects. The mechanism of action of amitriptyline is still not fully understood. However, amitriptyline works as an inhibitor of serotonin (5-hydroxytryptamine, 5HT [S0370]) or L-noradrenaline [A0906] re-uptake transporters in brain neurons. This inhibition is believed by some to underlie the antidepressant activity of amitriptyline. Amitriptyline undergoes extensive metabolism in the liver, primarily through N-demethylation, to nortriptyline [N0957]. (The product is for research purpose only.)
References
- Inhibition of uptake of tritiated-noradrenaline in the intact rat brain by imipramine and structurally related compounds
- Inhibition of the uptake of tritiated 5-hydroxytryptamine in brain tissue
- Amitriptyline hydrochloride (a review on the physical properties, synthesis, stability, metabolism, and analysis of amitriptyline-HCl)
- Amitriptyline A review of its pharmacological properties and therapeutic use in chronic pain states (a review)
- The Metabolic Fate of Amitriptyline, Nortriptyline and Amitriptylinoxide in Man (a review)
考研文獻
TCIMail
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