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CAS RN: 125-84-8 | 產品號碼: A1947
DL-Aminoglutethimide

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產品號碼 | A1947 |
純度/分析方法 | >98.0%(T)(HPLC) |
分子式 / 分子量 | C__1__3H__1__6N__2O__2 = 232.28 |
外觀與形狀(20°C) | Solid |
儲存條件 | Room Temperature (Recommended in a cool and dark place, <15°C) |
包裝和容器 | 1G-Glass Bottle with Plastic Insert (閲覽圖片) |
CAS RN | 125-84-8 |
Reaxys-RN | 210656 |
PubChem Substance ID | 87558926 |
Merck Index(14) | 440 |
MDL編號 | MFCD00010122 |
產品規格
Appearance | White to Light yellow powder to crystal |
Purity(HPLC) | min. 98.0 area% |
Purity(Nonaqueous Titration) | min. 98.0 % |
Melting point | 150.0 to 154.0 °C |
Solubility in Acetone | very faint turbidity |
NMR | confirm to structure |
性質
熔點 | 152 °C |
溶解性(可溶於) | Acetone |
GHS
圖形表示 |
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信號詞 | Warning |
危險性說明 | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
防範說明 | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
相關法規
RTECS # | MA4026950 |
運輸資料
HS編碼* | 2933.39-000 |
Application
DL-Aminoglutethimide: A Potent but Nonselective Aromatase Inhibitor
DL-Aminoglutethimide is a first generation, and a potent but nonselective aromatase inhibitor. Aminoglutethimide inhibits the enzymatic side-chain cleavage of cholesterol [C0318] to pregnenolone [P0786], mediated through the binding of aminoglutethimide to cytochrome P 450, resulting in a decrease in the production of adrenal glucocorticoids, mineralocorticoids, estrogens, and androgens. Besides, aminoglutethimide-P450 complexes block enzymatic 11- and 18-hydroxylation steps required for the aromatization of androgens to estrogens. Aminoglutethimide is used for the treatment of Cushing’s syndrome, breast and prostate cancer. (The product is for research purpose only.)
References
- Aminoglutethimide (Elipten) as an inhibitor of adrenal steroidogenesis: mechanism of action and therapeutic trial
- Stereoselective inhibition of aromatase by enantiomers of aminoglutethimide
- Regulation of intramitochondrial cholesterol transfer to side-chain cleavage cytochrome P-450 in rat adrenal gland
- Mechanisms of action of aminoglutethimide as endocrine therapy of breast cancer (a review)
- History of aromatase: saga of an important biological mediator and therapeutic target
考研文獻
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