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CAS RN: 91421-43-1 | 產品號碼: A2063
9-Aminocamptothecin
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產品規格
| Appearance | Light yellow to Yellow to Orange powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| NMR | confirm to structure |
性質
GHS
相關法規
| RTECS # | UQ0490500 |
運輸資料
| HS編碼* | 2939.79-000 |
Application
9-Aminocamptothecin (9-AC): A Water Insoluble Topoisomerase-I Inhibitor
9-Aminocamptothecin (9-AC) is a water insoluble derivative of camptothecin [C1495] with broad antitumor activity, and a metabolite of 9-nitrocamptothecin [N0822]. Camptotecin and its derivatives interfere with DNA synthesis by inhibiting the enzyme topoisomerase-I. In order to prevent and correct of topological problems caused by the DNA double helix, topoisomerase-I catalyzes the relaxation of negatively supercoiled DNA, the knotting and unknotting DNA and the linking complementary rings of single-stranded DNA into double-stranded rings. Then the inhibition action induces breaks in single strand DNA. Eventually, this leads to double-strand DNA breaks and apoptosis or cell death.
References
- Plant antitumor agents. 30. Synthesis and structure activity of novel camptothecin analogs
- Comparison of topoisomerase I inhibition, DNA damage, and cytotoxicity of camptothecin derivatives presently in clinical trials
- The clinical development of 9-Aminocamptothecin (a review)
- The camptothecins (a review)
- Analysis of the active lactone form of 9-aminocamptothecin in plasma using solid-phase extraction and high-performance liquid chromatography
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