Product Document Searching Made Easy by 2D Code! | TCI Chemistry News November 2025 | [TCIPracticalExample] The Z-Selective Horner-Wadsworth-Emmons Reaction... | Various analytical charts can be searched on each product detail page and Product Document Search (The kinds of analytical charts differ by product)
Maximum quantity allowed is 999
请选择数量
CAS RN: 68302-57-8 | 產品號碼: A2401
| 產品號碼 | A2401 |
純度/分析方法 
|
>98.0%(T)(HPLC) |
| 分子式 / 分子量 | C__1__6H__1__4N__2O__4 = 298.30 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| 儲存在惰性氣體下 | Store under inert gas |
| 應避免的情況 | Air Sensitive |
| 包裝和容器
|
1G-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 68302-57-8 |
| Reaxys-RN | 556384 |
| PubChem Substance ID | 160871486 |
| Merck Index(14) | 490 |
產品規格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
| NMR | confirm to structure |
性質
| 熔點 | 300 °C |
GHS
相關法規
| RTECS # | DJ3102000 |
運輸資料
| HS編碼* | 2934.99-000 |
Application
Amlexanox: A Specific Inhibitor of IKKε and TBK1 with Anti-Allergic Activity
Amlexanox (AA-673) is an anti-inflammatory and anti-allergic agent. The precise mechanism of action is known, but recently in vitro studies have demonstrate that amlexanox is a specific inhibitor of the protein kinases IκB kinase-ε (IKKε) and TANK-binding kinase 1 (TBK1) resulting in the inhibition of the formation and/or release of inflammatory mediators (histamine and leukotrienes) from mast cells, neutrophils and mononuclear cells. For your reference, [C2661] is a synthetic intermediate of amoxanox. (The product is for research purpose only.)
References
- Mechanism of action of an antiallergic agent, amlexanox (AA-673), in inhibiting histamine release from mast cells. Acceleration of cAMP generation and inhibition of phosphodiesterase
- Three distinct anti-allergic drugs, amlexanox, cromolyn and tranilast, bind to S100A12 and S100A13 of the S100 protein family
- Two distinct anti-allergic drugs, amlexanox and cromolyn, bind to the same kinds of calcium binding proteins, except calmodulin, in bovine lung extract
- Amlexanox reversibly inhibits cell migration and proliferation and induces the Src-dependent disassembly of actin stress fibers in Vitro
- An inhibitor of the protein kinases TBK1 and IKK-ε improves obesity-related metabolic dysfunctions in mice
- A validated stability indicating LC method for amlexanox in bulk drugs
PubMed Literature
文檔
產品介紹報導
產品文件 （部分產品的分析圖譜無法提供，敬請諒解。）
SDS
請選擇語言。
請求的SDS不可用。
如需更多幫助，請聯繫我們 。
產品規格
檢驗報告(CoA)及其他文檔
請輸入批號
輸入的批號不正確
示例 CoA
可下載CoA示例。注：該示例可能非最新批次的CoA。
目前沒有該產品的 CoA 示例。
分析圖譜
請輸入批號
輸入的批號不正確
很抱歉，您搜索的分析圖譜無法提供。