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CAS RN: 133550-35-3 | 產品號碼: A2704
Tyrphostin AG 494
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產品規格
| Appearance | Light yellow to Amber to Dark green powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(with Total Nitrogen) | min. 98.0 % |
| NMR | confirm to structure |
性質
| 熔點 | 249 °C(dec.) |
GHS
| 圖形表示 |
|
| 信號詞 | Danger |
| 危險性說明 | H301 : Toxic if swallowed. H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| 防範說明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
相關法規
運輸資料
| UN編號 | UN3439 |
| 類別 | 6.1 |
| 包裝類別 | III |
| HS編碼* | 2926.90-000 |
Application
Tyrphostin AG 494: A Potent and Selective Inhibitor of EGF Receptor (EGFR) Tyrosine Kinase
Tyrphostin AG 494, a member of tyrosine kinase inhibitors, is a potent and selective inhibitor of EGF receptor (EGFR) tyrosine kinase.
References
- Tyrphostins. II. Heterocyclic and α-substituted benzylidenemalononitrile tyrphostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases
- Selective inhibition of the epidermal growth factor and HER2/neu receptors by tyrphostins.
- Tyrphostin AG 494 blocks Cdk2 activation
- Tyrphostins Protect Neuronal Cells from Oxidative Stress
- Receptor-Guided Alignment-Based Comparative 3D-QSAR Studies of Benzylidene Malonitrile Tyrphostins as EGFR and HER-2 Kinase Inhibitors
- The effect of tyrphostins AG494 and AG1478 on the autocrine growth regulation of A549 and DU145 cells
考研文獻
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