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CAS RN: 141396-28-3 | 產品號碼: A2705
Argatroban Monohydrate
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| 產品號碼 | A2705 |
純度/分析方法 
|
>99.0%(HPLC) |
| 分子式 / 分子量 | C__2__3H__3__6N__6O__5S·H__2O = 526.66 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件
|
Refrigerated (0-10°C) |
| 應避免的情況 | Light Sensitive,Heat Sensitive |
| CAS RN | 141396-28-3 |
| 相關CAS RN
|
74863-84-6 |
| PubChem Substance ID | 253661816 |
| Merck Index(14) | 779 |
| MDL編號 | MFCD00895735 |
產品規格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 99.0 area% |
| Elemental analysis(Nitrogen) | 15.50 to 16.50 % |
| Specific rotation [a]20/D | +160.0 to +170.0 deg(C=0.8, MeOH)(calcd.on anh.substance) |
| Water | 2.5 to 4.5 % |
性質
| 熔點 | 180 °C(dec.) |
| 比旋光 [α]D | 165° (C=0.8,MeOH) |
| 水溶性 | Insoluble |
| 溶解性（微溶於） | Methanol |
| 溶解性（不溶於） | Ether, Acetone |
GHS
相關法規
| RTECS # | TM6126625 |
運輸資料
| HS編碼* | 2935.90-000 |
Application
Argatroban: A Direct Thrombin Inhibitor Act as an Anticoagulant
Argatroban is a synthetic selective thrombin inhibitor. It is known that argatroban exerts inhibiting activities on fibrin generation, platelet aggregation and vasoconstriction by direct interacting with thrombin. Due to these activities, argatoroban is utilized as an ingredient for anticoagulant and antithrombotic. Argatroban is also used as one of positive control drugs for thrombosis model animals. (This product is for research purpose only.)
References
- Comparative study on heparin and a synthetic thrombin inhibitor no. 805 (MD-805*) in experimental antithrombin III-deficient animals
- Potent inhibition of thrombin by the newly synthesized arginine derivative No. 805. The importance of stereo-structure of its hydrophobic carboxamide portion
- Selective inhibition of thrombin by (2R,4R)-4-methyl-1-[N2-[1,2,3,4-tetrahydro-8-quinolinyl)sulfonyl]-L-arginyl]-2-piperidinecarboxylic acid
- Antithrombotic actions of argatroban in rat models of venous, 'mixed' and arterial thrombosis, and its effects on the tail transection bleeding time
- Effects of a thrombin inhibitor, argatroban, on ischemic brain damage in the rat distal middle cerebral artery occlusion model.
- Argatroban (a review)
- Direct thrombin inhibitors in acute coronary syndromes: present and future (a review)
- Argatroban: Update (a review)
考研文獻
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