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CAS RN: 1451042-18-4 | 產品號碼: A2897
N-(2-Aminophenyl)-4-[1-[2-(3-thienyl)ethyl]-1H-1,2,3-triazol-4-yl]benzamide
![Chemical Structure of N-(2-Aminophenyl)-4-[1-[2-(3-thienyl)ethyl]-1H-1,2,3-triazol-4-yl]benzamide](/medias/A2897.jpg?context=bWFzdGVyfHJvb3R8NDkxMDZ8aW1hZ2UvanBlZ3xhRGN4TDJneU1pODRPVEU1TmpnMU1UTTJOREUwTDBFeU9EazNMbXB3Wnd8NTFhYmEyNTk5NmJhOGIzZTM2ZDM5YjZjYjFhMDc4ZDU0MDk2ZTNmNzBmN2Q3YWRiZjZjMjBlYTYwNDkxNjljYw "N-(2-Aminophenyl)-4-[1-[2-(3-thienyl)ethyl]-1H-1,2,3-triazol-4-yl]benzamide")
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![N-(2-Aminophenyl)-4-[1-[2-(3-thienyl)ethyl]-1H-1,2,3-triazol-4-yl]benzamide](/_ui/responsive/theme-tci/images/missing_product_zoom.jpg "N-(2-Aminophenyl)-4-[1-[2-(3-thienyl)ethyl]-1H-1,2,3-triazol-4-yl]benzamide")
| 包裝 | 價格 | 同一天 | 2-3个工作日 | 左側以上貨期 |
貨期資訊
|
|---|---|---|---|---|---|
| 5MG |
NT$5,586
|
5 | 4 | 下單後約3-4週內可以出貨 |
* 以上價格已含運費關稅等但一些需要海運以及乾冰運輸的產品除外,詳情請與
當地經銷商
洽詢。
* TCI會時常優化儲存條件,儲存溫度請以在線目錄為準，敬請留意。
| 產品號碼 | A2897 |
純度/分析方法 
|
>95.0%(HPLC) |
| 分子式 / 分子量 | C__2__1H__1__9N__5OS = 389.48 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件
|
Frozen (<0°C) |
| 儲存在惰性氣體下 | Store under inert gas |
| 應避免的情況 | Air Sensitive,Heat Sensitive |
| CAS RN | 1451042-18-4 |
| PubChem Substance ID | 354333140 |
產品規格
| Appearance | White to Yellow to Orange powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Elemental analysis(Nitrogen) | 17.00 to 19.00 % |
| NMR | confirm to structure |
性質
| 熔點 | 236 °C |
GHS
| 圖形表示 |
|
| 信號詞 | Warning |
| 危險性說明 | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| 防範說明 | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
相關法規
運輸資料
| HS編碼* | 2934.99-000 |
Application
A Histone Deacetylase 3 (HDAC3) Selective Inhibitor
Suzuki et al. have reported that this compound (T247) shows potent histone deacetylase 3 (HDAC3) inhibitions, whereas it does not strongly inhibit other isozymes. T247 also induces a dose-dependent selective NF-kB acetylation in human colon cancer HCT116 cells, indicating selective inhibition of HDAC3 in the cells. In addition, T247 induced growth inhibition of cancer cells, and activated HIV gene expression in latent HIV-infected cells. These findings indicate that T247 alone or a combination agent may be useful in the treatment of cancer or HIV infection. (The product is for research purpose only.)
References
- Identification of highly selective and potent histone deacetylase 3 inhibitors using click chemistry-based combinatorial fragment assembly
- Triazole ring-containing amides, their preparation, and their use for pharmaceuticals and HDAC3 inhibitors
- N. Miyata, T. Suzuki, Y. Kasuya, JP 2013-170164 A
考研文獻
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