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CAS RN: 102121-60-8 | 產品號碼: A3082
| 產品號碼 | A3082 |
| 純度/分析方法 | >98.0%(HPLC) |
| 分子式 / 分子量 | C__2__2H__2__5NO__3 = 351.45 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件 | Room Temperature (Recommended in a cool and dark place, <15°C) |
| 包裝和容器 | 100MG-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 102121-60-8 |
| Reaxys-RN | 3565084 |
| PubChem Substance ID | 468590144 |
| MDL編號 | MFCD00673916 |
產品規格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
性質
| 熔點 | 260 °C |
| Maximum Wavelength | 283 nm (EtOH(95vol%)) |
GHS
相關法規
| RTECS # | DH6834890 |
運輸資料
| HS編碼* | 2924.29-000 |
Application
AM580: A Retinoic Acid Receptor-α (RARα)-Selective Agonist
AM580, a stable retinobenzoic acid derivative, is a retinoic acid receptor-α (RARα)-selective agonist. Retinoids regulate a wide variety of essential biological processes. RARα is a member of retinoic acid receptors (RARs) which act as ligand-activated transcription factors controlling the expression of a number of target genes. It is reported that AM580 promotes the reprogramming of somatic cells to induced pluripotent stem cells and inhibits tumor cell proliferation. (The product is for research purpose only.)
References
- AM580, a stable benzoic derivative of retinoic acid, has powerful and selective cyto-differentiating effects on acute promyelocytic leukemia cells
- Retinobenzoic acids. 1. Structure-activity relationships of aromatic amides with retinoidal activity
- The Retinoic Acid Receptor-α mediates human T-cell activation and Th2 cytokine and chemokine production
- Novel non-carboxylic acid retinoids: 1,2,4-Oxadiazol-5-one derivatives
- Rapid and efficient reprogramming of somatic cells to induced pluripotent stem cells by retinoic acid receptor gamma and liver receptor homolog 1
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