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CAS RN: 330784-47-9 | 產品號碼: A3476
| 產品號碼 | A3476 |
純度/分析方法 
|
>98.0%(T)(HPLC) |
| 分子式 / 分子量 | C__2__3H__2__6ClN__7O__3 = 483.96 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件
|
Refrigerated (0-10°C) |
| 儲存在惰性氣體下 | Store under inert gas |
| 應避免的情況 | Air Sensitive,Heat Sensitive |
| 包裝和容器
|
1G-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 330784-47-9 |
| Reaxys-RN | 11746013 |
| MDL編號 | MFCD11977961 |
產品規格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 163.0 to 167.0 °C |
| Specific rotation | -62.0 to -72.0 deg (C=1, methanol) |
| NMR | confirm to structure |
性質
| 熔點 | 165 °C |
GHS
相關法規
運輸資料
| HS編碼* | 2933.59-000 |
Application
Avanafil: A Potent and Highly Selective Inhibitor of Phosphodiesterase-5 (PDE-5)
Avanafil is a potent and highly selective inhibitor of phosphodiesterase-5 (PDE-5), which is the predominant PDE isoenzyme in human corpora cavernosa. In there, nitric oxide (NO) activates the enzyme guanylate cyclase, which results in increased levels of cGMP. Avanafil enhances the effect of NO by inhibiting PDE5, which is responsible for degradation of cGMP in the corpus cavernosum. There are reports that avanafil has a favorable PDE-5 selectivity profile compare to that of other PDE-5 inhibitors, such as sildenafil citrate [S0986]. (The product is for research purpose only.)
References
- Avanafil, a Potent and Highly Selective Phosphodiesterase-5 Inhibitor for Erectile Dysfunction
- PDE5 inhibitors: considerations for preference and long-term adherence (a review)
- Development and validation of RP-HPLC method for simultaneous estimation of avanafil and dapoxentine hydrochloride in bulk and dosage form
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