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CAS RN: 118458-54-1 | 產品號碼: A3497
Arcyriaflavin A
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| 包裝 | 價格 | 同一天 | 2-3个工作日 | 左側以上貨期 |
貨期資訊
|
|---|---|---|---|---|---|
| 20MG |
NT$8,148
|
10 | 16 | 下單後約2週內可以出貨 |
* 以上價格已含運費關稅等但一些需要海運以及乾冰運輸的產品除外,詳情請與
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| 產品號碼 | A3497 |
純度/分析方法 
|
>90.0%(HPLC)(qNMR) |
| 分子式 / 分子量 | C__2__0H__1__1N__3O__2 = 325.33 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件
|
Frozen (-20°C) |
| 儲存在惰性氣體下 | Store under inert gas |
| 應避免的情況 | Air Sensitive,Heat Sensitive |
| CAS RN | 118458-54-1 |
| Reaxys-RN | 4557421 |
| MDL編號 | MFCD03452662 |
產品規格
| Appearance | Light yellow to Yellow to Orange powder to crystal |
| Purity(HPLC) | min. 90.0 area% |
| Purity(qNMR) | min. 90.0 % |
| NMR | confirm to structure |
性質
GHS
相關法規
運輸資料
| HS編碼* | 2933.99-000 |
Application
Arcyriaflavin A: A Potent Inhibitor of Protein Kinases
Arcyriaflavin A is an important member of the indolocarbazole alkaloid family, and was first isolated in 1980 from the slime mold Arcyria denudata.1) This family has potential therapeutic application in the treatment of cancer because of its ability to inhibit protein kinases.2,3) Thera are reports that arcyriaflavin A inhibits cyclin-dependent kinase 4 (CDK49 and calcium/calmodulin-dependent protein kinase II (CaMKII).3,4) It also inhibits proliferation and induces apoptosis of endometriotic cyst stromal cells (ECSCs).5) In addition, arcyriaflavin A has been used a key synthetic intermediate of indolocarbazole alkaloids such as staurosporinone [T4000] which is a protein kinase C (PKC) and leucine-rich repeat kinase 2 (LRRK2) inhibitor.6) (The product is for research purpose only.)
References
- 1) Indole Pigments from the Fruiting Bodies of the Slime Mold Arcyria denudata
- 2) Indolocarbazole natural products: occurrence, biosynthesis, and biological activity
- 3) Arcyriaflavin A monohydrate
- 4) Aryl[a]pyrrolo[3,4-c]carbazoles as selective cyclin D1-CDK4 inhibitorss
- 5) Arcyriaflavin a, a cyclin D1–cyclin-dependent kinase4 inhibitor, induces apoptosis and inhibits proliferation of human endometriotic stromal cells: a potential therapeutic agent in endometriosis
- 6) An account of synthetic strategies towards indolocarbazole alkaloids: Arcyriaflavin A and staurosporinone (a review)
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