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CAS RN: 329196-48-7 | 產品號碼: A3537
| 產品號碼 | A3537 |
| 純度/分析方法 | >98.0%(T)(HPLC) |
| 分子式 / 分子量 | C__2__6H__2__6ClN__3O__4 = 479.96 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件 | Refrigerated (0-10°C) |
| 儲存在惰性氣體下 | Store under inert gas |
| 應避免的情況 | Light Sensitive,Air Sensitive,Heat Sensitive |
| CAS RN | 329196-48-7 |
| Reaxys-RN | 12773727 |
產品規格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 215.0 to 219.0 °C |
| NMR | confirm to structure |
性質
| 熔點 | 217 °C |
GHS
相關法規
運輸資料
| HS編碼* | 2933.99-000 |
Application
SANT-2: A Smoothened (Smo) Receptor Antagonist
SANT-2 is a Smoothened (Smo) receptor antagonist. Smo, a Class Frizzled (Class F) G protein-coupled receptors, mediates Hedgehog (Hh) signaling that controls growth, cell fate decisions, and morphogenesis during development. There are reports that SANT-2 inhibits Smo activity and Hh signaling induced by an N-terminal fragment of sonic hedgehog (Shh). In addition, SANT-2 has been used in cancer research, as aberrant activation of the Hh signaling pathway has been implicated in a variety of cancers.
References
- Small molecule modulation of Smoothened activity
- J. K. Chen, J. Taipale, K. E. Young, T. Maiti, P. A. Beachy, Proc. Natl. Acad. Sci. 2002, 99, 14071.
- Evidence for allosteric interactions of antagonist binding to the Smoothened receptor
- Synthesis and biological evaluation of SANT-2 and analogues as inhibitors of the hedgehog signaling pathway
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