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CAS RN: 151060-21-8 | 產品號碼: B4354
Balofloxacin Dihydrate

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產品號碼 | B4354 |
純度/分析方法 ![]() |
>98.0%(T)(HPLC) |
分子式 / 分子量 | C__2__0H__2__4FN__3O__4·2H__2O = 425.46 |
外觀與形狀(20°C) | Solid |
儲存條件 ![]() |
Room Temperature (Recommended in a cool and dark place, <15°C) |
包裝和容器 ![]() |
1G-Glass Bottle with Plastic Insert (閲覽圖片) |
CAS RN | 151060-21-8 |
相關CAS RN ![]() |
127294-70-6 |
Reaxys-RN | 8362117 |
PubChem Substance ID | 253661053 |
MDL編號 | MFCD00864925 |
產品規格
Appearance | White to Almost white powder to crystal |
Purity(HPLC) | min. 98.0 area% |
Purity(Neutralization titration) | min. 98.0 %(as Dihydrate) |
Water | 6.5 to 10.5 % |
性質
熔點 | 135 °C |
GHS
相關法規
RTECS # | VB1993755 |
運輸資料
HS編碼* | 2933.49-000 |
Application
Balofloxacin: An 8-Methoxyfluoroquinolone Antibiotic
Balofloxacin (Q-35) is a fluoroquinolone antibiotic, in which a OMe group is substituted at the 8 position of the quinoline nucleus. In vitro, it has a broad spectrum of activity against Gram-positive bacteria (eg. Mycoplasma pneumoniae and Staphylococcus aureus including MRSA) which is almost equal to that of sparfloxacin [S0896] or tosufloxacin [T2506]. In contrast, its activity against Gram-negative bacteria is lower. In animal studies, balofloxacin do not exhibit any phototoxicity which is a toxicity of fluoroquinolone antibiotic, in general.
References
- In vitro and in vivo activities of Q-35, a new fluoroquinolone, against Mycoplasma pneumoniae
- Improved bactericidal activity of Q-35 against quinolone-resistant staphylococci
- Photostability and biological activity of fluoroquinolones substituted at the 8 position after UV irradiation
- Reduced phototoxicity of a fluoroquinolone antibacterial agent with a methoxy group at the 8 position in mice irradiated with long-wavelength UV light
- Laboratory and clinical study of balofloxacin (Q-35), a new fluoroquinolone, in urinary tract infection
- Development and validation of analytical method for estimation of Balofloxacin in bulk and pharmaceutical dosage form
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