Maximum quantity allowed is 999
请选择数量
CAS RN: 153559-49-0 | 產品號碼: B4798
| 產品號碼 | B4798 |
純度/分析方法 
|
>96.0%(HPLC) |
| 分子式 / 分子量 | C__2__4H__2__8O__2 = 348.49 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件
|
Frozen (-20°C) |
| 應避免的情況 | Heat Sensitive |
| 包裝和容器
|
100MG-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 153559-49-0 |
| Reaxys-RN | 7041961 |
| PubChem Substance ID | 354333139 |
| Merck Index(14) | 1194 |
| MDL編號 | MFCD00932428 |
產品規格
| Appearance | White to Orange to Green powder to crystal |
| Purity(HPLC) | min. 96.0 area% |
| Melting point | 220.0 to 225.0 °C |
性質
| 熔點 | 222 °C |
| Maximum Wavelength | 264 nm (MeOH) |
| 溶解性（微溶於） | Ethanol |
GHS
| 圖形表示 |
|
| 信號詞 | Warning |
| 危險性說明 | H361 : Suspected of damaging fertility or the unborn child. H413 : May cause long lasting harmful effects to aquatic life. |
| 防範說明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P273 : Avoid release to the environment. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P405 : Store locked up. |
相關法規
| RTECS # | DH6834830 |
運輸資料
| HS編碼* | 2916.39-000 |
Application
Bexarotene: A Selective Retinoid X Receptor (RXR) Agonist
Retinoids are biological active analogs of vitamin A, which play essential roles in embryonic or adult cell behavior modulating cell proliferation, differentiation and apoptosis. Bexarotene, a synthetic retinoid known as LGD1069, selectively binds to and activates retinoid X receptors (RXRs). Thereby, bexarotene induces change in gene expression that lead to cell differentiation, decreased cell proliferation, apoptosis of some cancer cell types, and tumor regression. Recently, bexarotene has been reported that it acts to reduce harmful β-amyloid protein which has been suspected as a key contributor to Alzheimer’s disease. (The product is for research purpose only.)
References
- Chemoprevention of mammary carcinoma by LGD1069 (Targretin): an RXR-selective ligand
- Sensitization of diabetic and obese mice to insulin by retinoid X receptor agonists
- How retinoids regulate breast cancer cell proliferation and apoptosis (a review)
- Bexarotene: a promising anticancer agent (a review)
- ApoE-Directed Therapeutics Rapidly Clear β-Amyloid and Reverse Deficits in Alzheimer's disease Mouse Models
- Studies cast doubt on cancer drug as Alzheimer's treatment (News)
考研文獻
文檔
產品介紹報導
產品文件 （部分產品的分析圖譜無法提供，敬請諒解。）
SDS
請選擇語言。
請求的SDS不可用。
如需更多幫助，請聯繫我們 。
產品規格
檢驗報告(CoA)及其他文檔
請輸入批號
輸入的批號不正確
示例 CoA
可下載CoA示例。注：該示例可能非最新批次的CoA。
目前沒有該產品的 CoA 示例。
分析圖譜
請輸入批號
輸入的批號不正確
很抱歉，您搜索的分析圖譜無法提供。