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CAS RN: 196309-76-9 | 產品號碼: B4845
| 產品號碼 | B4845 |
純度/分析方法 
|
>97.0%(N) |
| 分子式 / 分子量 | C__1__3H__1__5NO__2S = 249.33 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件
|
Refrigerated (0-10°C) |
| 儲存在惰性氣體下 | Store under inert gas |
| 應避免的情況 | Air Sensitive,Heat Sensitive |
| 包裝和容器
|
10MG-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 196309-76-9 |
| Reaxys-RN | 9999499 |
| PubChem Substance ID | 354333080 |
| MDL編號 | MFCD01862602 |
產品規格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(with Total Nitrogen) | min. 97.0 % |
| Melting point | 82.0 to 86.0 °C |
| NMR | confirm to structure |
性質
| 熔點 | 84 °C |
GHS
| 圖形表示 |
|
| 信號詞 | Warning |
| 危險性說明 | H302 : Harmful if swallowed. H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| 防範說明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
相關法規
| RTECS # | UD1312500 |
運輸資料
| HS編碼* | 2930.90-900 |
Application
Bay 11-7085: An Inhibitor of NFκB and IκBα Phosphorylation
Bay 11-7085 and Bay 11-7082 [T2846] are inhibitors of nuclear factor-κB (NFκB) and phosphorylation of IκBα. They have been shown to inhibit cell proliferation and induce apoptosis of a variety of cells. NFκB is a protein complex controls transcription of DNA and inflammatory cytokine production. Researches demonstrate that inhibition of NFκB can suppress the angiogenic potential and metastasis of cancer cells. IκBα is one member of a family of cellular proteins that function to inhibit the NF-κB transcription factor. In addition, they have anti-inflammatory activity.
References
- An IκBα inhibitor causes leukemia cell death through a p38 MAP kinase-dependent, NF-κB-independent mechanism
- Inhibition of Inhibitor of Nuclear Factor-κB Phosphorylation Increases the Efficacy of Paclitaxel in in Vitro and in Vivo Ovarian Cancer Models
- 15-Deoxy-Δ12,14-prostaglandin J2 inhibits Bay 11-7085-induced sustained extracellular signal-regulated kinase phosphorylation and apoptosis in human articular chondrocytes and synovial fibroblasts
- Nuclear factor-κB inhibitors as sensitizers to anticancer drugs (a review)
考研文獻
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