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CAS RN: 877399-00-3 | 產品號碼: B5682
(R)-5-Bromo-3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]pyridin-2-amine
![Chemical Structure of (R)-5-Bromo-3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]pyridin-2-amine](/medias/B5682.jpg?context=bWFzdGVyfHJvb3R8NTIwOTd8aW1hZ2UvanBlZ3xhREl4TDJobE55ODRPVEl3TXprNU1ESXdNRFl5TDBJMU5qZ3lMbXB3Wnd8OWUyMDBjOGNmMDIxNWY0YjdkMzFkMmJkYzJhZjMxNWY0MmVjY2ZjZDZhNjRjMjM1MTY0MGVkMGEyY2QyMDRkNA "(R)-5-Bromo-3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]pyridin-2-amine")
![Thumbnail of (R)-5-Bromo-3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]pyridin-2-amine](/medias/B5682.jpg?context=bWFzdGVyfHJvb3R8MTU4OTd8aW1hZ2UvanBlZ3xhREV5TDJnM1pDODRPVE16T0RFeU56azNORGN3TDBJMU5qZ3lMbXB3Wnd8ZjAzMDdiODg1YTkwM2UyMzk3YTM3OGE5NGRiMmIwOWU0MDZkMTg1NmJjYmRmMTI0MmM0NjI3ZjU2YWQwZDkxNA)
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![(R)-5-Bromo-3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]pyridin-2-amine](/_ui/responsive/theme-tci/images/missing_product_zoom.jpg "(R)-5-Bromo-3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]pyridin-2-amine")
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| 產品號碼 | B5682 |
純度/分析方法 
|
>98.0%(HPLC) |
| 分子式 / 分子量 | C__1__3H__1__0BrCl__2FN__2O = 380.04 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| 包裝和容器
|
1G-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 877399-00-3 |
| Reaxys-RN | 12134679 |
| PubChem Substance ID | 354335323 |
| MDL編號 | MFCD18207061 |
產品規格
| Appearance | White to Light yellow to Light orange powder to crystal |
| Specific rotation(value) | -64.0 to -70.0 deg(C=1, CHCL3) |
| Purity(HPLC) | min. 98.0 area% |
| Purity(with Total Nitrogen) | min. 98.0 % |
| Melting point | 108.0 to 113.0 °C |
性質
| 熔點 | 109 °C |
| 比旋光 [α]D | -67° (C=1,CHCl3) |
GHS
| 圖形表示 |
|
| 信號詞 | Warning |
| 危險性說明 | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| 防範說明 | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
相關法規
運輸資料
| HS編碼* | 2933.39-000 |
Application
A Synthetic Intermediate of Tyrosine Kinase Inhibitors
This product has been used as a synthetic intermediate of tyrosine kinase inhibitors, such as crizotinib (PF-02341066).
References
- Structure Based Drug Design of Crizotinib (PF-02341066), a Potent and Selective Dual Inhibitor of Mesenchymal-Epithelial Transition Factor (c-MET) Kinase and Anaplastic Lymphoma Kinase (ALK)
- Fit-for-Purpose Development of the Enabling Route to Crizotinib (PF-02341066)
- Synthesis of a Crizotinib Intermediate via Highly Efficient Catalytic Hydrogenation in Continuous Flow
Application
A Key Synthetic Intermediate of Crizotinib
Structure Based Drug Design of Crizotinib (PF-02341066), a Potent and Selective Dual Inhibitor of Mesenchymal-Epithelial Transition Factor (c-MET) Kinase and Anaplastic Lymphoma Kinase (ALK)
References
- Structure Based Drug Design of Crizotinib (PF-02341066), a Potent and Selective Dual Inhibitor of Mesenchymal-Epithelial Transition Factor (c-MET) Kinase and Anaplastic Lymphoma Kinase (ALK)
- Fit-for-Purpose Development of the Enabling Route to Crizotinib (PF-02341066)
考研文獻
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