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CAS RN: 193551-21-2 | 產品號碼: B5898
產品規格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| NMR | confirm to structure |
性質
| 熔點 | 207 °C |
GHS
相關法規
| RTECS # | GV9458000 |
運輸資料
| HS編碼* | 2933.59-000 |
Application
SB 239063: A Selective p38 Mitogen-Activated Protein Kinase (MAPK) Inhibitor
SSB 239063 is a selective p38 mitogen-activated protein kinase (MAPK) inhibitor. It displays greater than 220-fold selectivity for p38 MAPK over other kinases.1) The p38 MAPK has been linked to inflammatory cytokine production and cell death in cellular stress. SB 239063 has been shown to reduce inflammatory cytokine production.1-4)
References
- 1) SB 239063, a potent p38 MAP kinase inhibitor, reduces inflammatory cytokine production, airways eosinophil infiltration, and persistence
- 2) SB 239063, a p38 MAPK inhibitor, reduces neutrophilia, inflammatory cytokines, MMP-9, and fibrosis in lung
- 3) Inhibition of p38 mitogen-activated protein kinase provides neuroprotection in cerebral focal ischemia (a review)
- 4) SB 239063, a second-generation p38 mitogen-activated protein kinase inhibitor, reduces brain injury and neurological deficits in cerebral focal ischemia
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