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CAS RN: | 產品號碼: B6160
BGP-15 Hydrochloride
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| 產品號碼 | B6160 |
純度/分析方法 
|
>98.0%(HPLC) |
| 分子式 / 分子量 | C__1__4H__2__2N__4O__2·xHCl |
| 外觀與形狀（20°C） | Solid |
| 儲存條件
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| 儲存在惰性氣體下 | Store under inert gas |
| 應避免的情況 | Hygroscopic |
| 相關CAS RN
|
459809-32-6&66611-37-8 |
產品規格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Melting point | 200.0 to 204.0 °C |
| NMR | confirm to structure |
性質
| 熔點 | 202 °C |
GHS
相關法規
運輸資料
| HS編碼* | 2933.39-000 |
Application
BGP-15: A PARP Inhibitor and an Insulin Sensitizer
Poly (ADP-ribose) polymerases (PARPs) is a family of enzymes involved in a number of cellular processes such as DNA repair, genomic stability, and apoptosis.1) BGP-15 has been used in cancer research because of its PARP inhibition.2) In addition, BGP-15 has recently reported as a pharmacological inducer of heat shock protein 72 (HSP72) and a new insulin sensitizer agent candidate.3,4) (The product is for research purpose only.)
References
- 1) Role of PARP Inhibitors in Cancer Biology and Therapy
- 2) Effect of Poly(ADP-Ribose) Polymerase Inhibitors on the Ischemia-Reperfusion-Induced Oxidative Cell Damage and Mitochondrial Metabolism in Langendorff Heart Perfusion System
- 3) HSP72 protects against obesity-induced insulin resistance
- 4) Pharmacological overview of the BGP-15 chemical agent as a new drug candidate for the treatment of symptoms of metabolic syndrome
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