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CAS RN: 471-95-4 | 產品號碼: B6325
| 產品號碼 | B6325 |
純度/分析方法 
|
>98.0%(HPLC) |
| 分子式 / 分子量 | C__2__6H__3__6O__6 = 444.57 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 471-95-4 |
| Reaxys-RN | 63218 |
| Merck Index(14) | 1477 |
| MDL編號 | MFCD00210248 |
產品規格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Specific rotation | +3.0 to +5.0 deg(C=0.5, CHCl3) |
| NMR | confirm to structure |
性質
GHS
| 圖形表示 |
|
| 信號詞 | Danger |
| 危險性說明 | H300 + H310 : Fatal if swallowed or in contact with skin. |
| 防範說明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P262 : Do not get in eyes, on skin, or on clothing. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing. P361 + P364 : Take off immediately all contaminated clothing and wash it before reuse. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P302 + P352 + P310 : IF ON SKIN: Wash with plenty of water. Immediately call a POISON CENTER/doctor. P405 : Store locked up. |
相關法規
| RTECS # | EI3150000 |
運輸資料
| UN編號 | UN2811 |
| 類別 | 6.1 |
| 包裝類別 | I |
| HS編碼* | 2932.20-000 |
Application
Bufotalin: A Cardiotonic Phytosteroid with Anti-Tumor Activities
Bufotalin is a cardiotonic phytosteroid and an active compound of the traditional Chinese medicine ChanSu which exhibits significant anti-tumor activities in many solid tumors and leukemia cell lines. There are reports that bufotalin introduces apoptosis, and prevents migration and invasion of tumor cells. Hence, bufotalin has attracted attention in recent years as an anti-tumor agent. (The product is for research purpose only.)
References
- 1) Bufotalin from Venenum Bufonis inhibits growth of multidrug resistant HepG2 cells through G2/M cell cycle arrest and apoptosis
- 2) Anti-tumor activity and apoptosis-regulation mechanisms of bufalin in various cancers: new hope for cancer patients
- 3) Involvement of Caspases and Apoptosis-Inducing Factor in Bufotalin-Induced Apoptosis of Hep 3B Cells
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